Table 1.
Values of IC50 for frog sciatic nerve CAP peak amplitude reductions by aroma oil compounds and of the logarithum of their Kow.
| Group | Compound | IC50 (mmol/L) | log Kow |
|---|---|---|---|
| Phenols | Carvacrol*1 | 0.34 | 3.49 |
| Thymol*1 | 0.34 | 3.30 | |
| Eugenol*2 | 0.81 | 2.49 | |
| Aldehydes | Citral | 0.46 (3.6) | 3.45 |
| Citronellal | 0.50 (3.8) | 3.53 | |
| Esters | Linalyl acetate | 0.71 (1.6) | 3.93 |
| Geranyl acetate | 0.51 (1.1) | 4.04 | |
| Bornyl acetate | 0.44 (2.2) | 3.86 | |
| Alcohols | Citronellol | 0.35 (3.1) | 3.91 |
| Geraniol | 0.53 (3.3) | 3.56 | |
| (±)-Linalool | 1.7 (1.8) | 2.97 | |
| (−)-Linalool | 2.0 (2.0) | − | |
| (+)-Borneol | 1.5 (3.0) | 2.85 | |
| (−)-Borneol | 2.3 (2.9) | 3.01 | |
| α-Terpineol | 2.7 (4.0) | 2.98 | |
| (−)-Menthol*1 | 1.1 | 3.3 | |
| (+)-Menthol*1 | 0.93 | − | |
| Ketones | (+)-Pulegone*1 | 1.4 | 3.08 |
| (−)-Carvone*1 | 1.4 | 2.71 | |
| (+)-Carvone*1 | 2.0 | 3.07 | |
| (−)-Menthone*1 | 1.5 | 3.05 | |
| (+)-Menthone*1 | 2.2 | − | |
| Oxides | Rose oxide | 2.6 (2.8) | − |
| 1,8-Cineole*1 | 5.7 | 2.74 | |
| 1,4-Cineole*1 | 7.2 | 2.97 |
Value in parentheses, next to IC50, indicates nH used to obtain the IC50 value in the present work. Data for the compounds denoted as *1 and *2, and of log Kow were taken from Kawasaki et al. (2013), Tomohiro et al. (2013), and ChemlDplus (2014), respectively. CAP, compound action potential; nH, Hill coefficient.