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. 2015 Feb 10;3(2):e00119. doi: 10.1002/prp2.119

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© 2015 The Authors. Pharmacology Research & Perspectives published by John Wiley & Sons Ltd, British Pharmacological Society and American Society for Pharmacology and Experimental Therapeutics.

This is an open access article under the terms of the Creative Commons Attribution-NonCommercial-NoDerivs License, which permits use and distribution in any medium, provided the original work is properly cited, the use is non-commercial and no modifications or adaptations are made.

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Maximal effects of repeated DM199 and bradykinin administration in the human isolated umbilical vein contractility assay. (A) Repeated effect of 10 nmol/L BK at 1 h intervals. ANOVA indicated that values were homogeneous (P > 0.05). (B) Repeated effect of DM199, followed by BK stimulation. The 2nd and 3rd effects of the protease at 1 or 10 nmol/L were significantly inferior to the 1st effect (ANOVA followed by Dunnett's test, P < 0.01).