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. 2015 Mar 25;3(2):e00132. doi: 10.1002/prp2.132

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© 2015 The Authors. Pharmacology Research & Perspectives published by John Wiley & Sons Ltd, British Pharmacological Society and American Society for Pharmacology and Experimental Therapeutics.

This is an open access article under the terms of the Creative Commons Attribution-NonCommercial-NoDerivs License, which permits use and distribution in any medium, provided the original work is properly cited, the use is non-commercial and no modifications or adaptations are made.

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Evaluation of protective effects against CORT-induced depression-like behavior. Mice were treated orally once a day with vehicle or compound A, B, or C (0.3 or 1.5 mg/kg body weight) for 21 days while being treated daily with vehicle or CORT (see protocol A in Fig.2). Then, the time immobilized was measured by performing the TST. The significance of the difference between the value of the CORT-treated group and that of the vehicle-treated group was determined by one-way ANOVA with Tukey's post hoc test, as **P < 0.01 (n = 6/group). Among the CORT-treated groups, significant differences from the value of the vehicle-treated group were also determined by performing one-way ANOVA with Tukey's test, as #P < 0.05 (n = 6/group). TST, tail suspension test. ANOVA, analysis of variance.