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. 2015 Mar 31;3(2):e00129. doi: 10.1002/prp2.129

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© 2015 The Authors. Pharmacology Research & Perspectives published by John Wiley & Sons Ltd, British Pharmacological Society and American Society for Pharmacology and Experimental Therapeutics.

This is an open access article under the terms of the Creative Commons Attribution License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited.

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UGE values in mice treated with two doses of 60 mg/kg LP-925219. DKO, S2 KO, S1 KO, and WT littermate mice received, by oral gavage at 8 am and then again at 6 pm, either vehicle (Veh) or LP-925219 at a dose of 60 mg/kg. The mice were placed in metabolic cages after the first gavage and their urine was collected over the next 24 h and analyzed for total glucose. N = 6–11 mice/group. UGE < DKO UGE, ***P < 0.001; LP-925219 UGE > Veh UGE for the same group, ^^^P < 0.001. UGE, urinary glucose excretion.