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LP-925219 inhibits SGLT-mediated glucose transport.
| Species | SGLT1 IC50 (nmol/L) | N | SGLT2 IC50 (nmol/L) | N |
|---|---|---|---|---|
| Mouse | 22.6 ± 1.0 | 5 | 0.5 ± 0.1 | 4 |
| Rat | 36.7 ± 7.2 | 3 | 0.3 ± 0.2 | 3 |
| Dog | 30.2 ± 2.0 | 5 | 1.0 ± 0.3 | 4 |
| Human | 15.9 ± 4.2 | 11 | 2.1 ± 0.5 | 11 |
Data are mean ± SD; N, number of determinations. SGLT2, sodium/glucose cotransporter 1.
