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Pharmacokinetic parameters after a 1 mg/kg intravenous dose of LP-925219.
| Half-life (h) | Cmax (nmol/L) | AUC0-t (nmol/L × h) | AUC0-∞ (nmol/L × h) | CL (mL/min per kg) | Vss (L/kg) |
|---|---|---|---|---|---|
| 2.8 ± 0.7^ | 1436 ± 971 | 1214 ± 121 | 1409 ± 40^ | 29 ± 1^ | 4.4 ± 0.6^ |
Data are mean ± SD; Cmax, plasma peak concentration; AUC0-t, AUC from time 0 to time of last measured concentration at time t (Ct); AUC0-∞, AUC0-t + Ct/λ; CL, clearance; Vss, volume of distribution at steady state.
N = 4; ^N = 3.
