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Pharmacokinetic parameters after a 10 mg/kg oral dose of LP-925219.
| Half-life (h) | Tmax (h) | Cmax (nmol/L) | AUC0–t (nmol/L × h) | AUC0-∞ (nmo/L*h) | %F (h) |
|---|---|---|---|---|---|
| 7.0 ± 0.9 | 0.3 ± 0 | 3164 ± 802 | 11,164 ± 2,507 | 12,214 ± 3037 | 87 ± 21 |
Data are mean ± SD; N = 4 for each parameter; Tmax, time of plasma peak concentration; Cmax, plasma peak concentration; AUC0-t, AUC from time 0 to time of last measured concentration at time t (Ct); AUC0-∞, AUC0-t + Ct/λ; %F, bioavailability.
