Table 3.

Parameter estimates and performance statistics for E7070 real data set

	Discard	LLOQ/2	LIKE	All data
CL (L/h)	0.823	0.819	0.822	0.828
V (L)	5.61	5.65	5.61	5.63
Q (L/h)	1.90	1.89	1.9	1.88
Vper (L)	12.4	12.5	12.4	12.6
ηCL	62.3%	61.5%	61.8%	60.6%
σadd (mg/L)	0.071	0.0344	0.055	0.0364
σprop	25.8%	26.6%	26.1%	26.7%
Successful minimization	74.1%	69.7%	66.7%	91.5%
Successful covariance step	14.4%	7.5%	11.4%	85.7%

LLOQ, lower limit of quantification; LIKE, likelihood-based.