Table 2.
GreenScreen™ (Cyprotex) analysis of rexinoids for cytotoxicity and mutagenicity.
| Without S9 activation | With S9 activation | |||
|---|---|---|---|---|
| Cytotoxicity (μg/mL) | Genotoxicity | Cytotoxicity (μg/mL) | Genotoxicity | |
| 1 | 1.12 | None | 18 | None |
| 2 | 0.74 | None | 47.3 | None |
| 4 | 1.33 | None | 21.3 | None |
| 7 | 6.64 | None | 213 | None |
| 9 | 8.57 | None | None | None |
| 14 | 1.06 | None | 33.9 | 33.9 μg/mL |
Rexinoids were added to TK6 cells to assess cytotoxicity and mutagenicity, as assayed by cell viability (cytotoxicity) and GFP expression (mutagenicity). Shown is the lowest effective concentration (LEC) for a positive result.