Table 3.

Blood cholesterol concentration after treatment of 100 mg/kg compound or vehicle control.

	Predose	1 h	2 h	3 h	6 h	9 h	12 h	24 h
Vehicle	110 ± 12.5	104 ± 12.1	94 ± 11.2	93 ± 8.4	101 ± 9	103 ± 13.4*	94 ± 8.7*	82 ± 2.1*
Bexarotene	105 ± 7.2	108 ± 14.4	93 ± 15.3	91 ± 9.6	89 ± 15.6	73 ± 10.7^	61 ± 13.8^	52 ± 6.6^
2	100 ± 21.2	122 ± 17.2	78 ± 6.2	95 ± 16.5	71 ± 12.8^	80 ± 14	65 ± 13^	47 ± 8^
4	106 ± 1	100 ± 16.1	87 ± 4.9	81 ± 14.8	83 ± 7.5^	66 ± 15.1^	66 ± 10.6^	50 ± 11^
7	108 ± 12	107 ± 20.1	92 ± 17.5	85 ± 12.9	89 ± 16	73 ± 10.7^	62 ± 4.7^	47 ± 7.5^
9	91 ± 8.1	99 ± 7.5	81 ± 6.5	80 ± 10.8	75 ± 4.7^	68 ± 9.9^	50 ± 4.5^	49 ± 5.7^
14	111 ± 13.7	124 ± 6.7	98 ± 9.0	102 ± 12.5	97 ± 10.4	93 ± 12.5*	72 ± 11.9^	100 ± 21*

Male Sprague–Dawley rats were treated with 100 mg/kg compound in sesame oil or sesame oil alone (vehicle control). Blood was taken at the indicated time points and analyzed for cholesterol composition in mg/dL. Statistical analysis was performed using a one-tailed Mann–Whitney test. Statistically significantly different than: *bexarotene treatment P ≤ 0.05; ^vehicle control P ≤ 0.05.