Table 9.
Differential expression of genes in rat brain after 24 h treatment with RXR ligand.
| Gene | Protein | 1 | 2 | 4 | 7 | 9 | 14 |
|---|---|---|---|---|---|---|---|
| Inmt | Indolethylamine N-methyltransferase | −0.23 | 1.93 | −0.41 | −0.82 | −0.36 | −0.13 |
| Ccl6 | Chemokine (C-C motif) ligand 6 | 0.054 | 0.66 | −0.91 | −1.46 | −1.39 | −1.68 |
| Mta2 | Metastasis-associated 1 family, member 2 | 0.97 | 1.88 | −0.10 | −1.36 | −0.34 | −1.45 |
| Cyp26b1 | Cytochrome P450 family 26, subfamily B, polypeptide 1 | −0.020 | 1.94 | 0.15 | −0.28 | −0.07 | −0.090 |
| Stra6 | Retinol-binding protein receptor | 0.05 | 1.58 | 0.23 | −0.05 | 0.13 | 0.22 |
| Angpt14 | Angiopoietin-related protein 4 | 0.18 | 0.28 | −0.31 | −1.11 | −0.64 | −1.43 |
| Pdk4 | mt pyruvate dehydrogenase lipoamide kinase isozyme 4 | 0.77 | 0.87 | −0.04 | −0.44 | −0.07 | −0.61 |
| Nmb | Neuromedin B | 0.166 | 1.28 | 0.33 | −0.38 | 0.20 | −1.00 |
| Epha3 | EPH receptor A3 | −0.34 | −0.89 | −0.27 | 0.34 | 0.007 | −0.49 |
| Lyve1 | Lymphatic vessel endothelial hyaluronan receptor 1 | 0.093 | 0.79 | −0.13 | −0.049 | −0.097 | −0.052 |
| LOC689600 | Uncharacterized and highly conserved | −0.52 | −0.99 | −0.43 | 0.53 | −0.037 | −0.55 |
| Vom2r8 | Vomeronasal 2 receptor, 8 | −0.21 | −0.27 | −0.62 | 0.074 | −0.85 | −0.51 |
| Mir346 | microRNA 346 | −0.12 | 0.002 | 0.81 | 0.17 | 0.52 | 0.30 |
| Acot1 | Acyl-CoA thioesterase 1 | −0.31 | −0.02 | 0.41 | −0.93 | −0.65 | −1.14 |
| Mir3556b | microRNA mir-3556b | −1.13 | −0.95 | −0.23 | −0.38 | −0.14 | 0.11 |
| Cyp26a1 | Cytochrome P450 26A1 | 0.46 | 1.00 | 0.061 | −0.088 | 0.002 | 0.15 |
| Abca1 | ATP-binding cassette transporter ABCA1 | −0.025 | 0.17 | 0.19 | −2.06 | −1.04 | −1.78 |
| Aurkb | Aurora kinase B | 0.11 | 0.90 | 0.43 | 0.34 | 0.25 | 0.40 |
| Ust5r | Integral membrane transport protein | −0.94 | −1.68 | −0.14 | 0.054 | 0.089 | 0.28 |
| Upp1 | Uridine phosphorylase 1 | 0.38 | 0.78 | 0.20 | −0.700 | 0.055 | −0.33 |
| LOC500594 | Ribosomal protein | −0.20 | 0.63 | 0.78 | 0.20 | 0.55 | 0.48 |
| Rbp1 | Retinol-binding protein 1 | −0.48 | 0.62 | −0.19 | −0.58 | −0.36 | −0.63 |
| Sycp2 | Synaptonemal complex protein | −0.18 | −0.25 | 0.24 | 0.048 | 0.69 | −0.28 |
| Alb | Albumin | −0.17 | −2.90 | −2.67 | −0.46 | −2.52 | −2.54 |
| Ifit3 | Interferon-induced protein with tetratricopeptide repeats 3 | −0.82 | −0.88 | 0.50 | −0.88 | −0.083 | −0.37 |
| Arl11 | ADP-ribosylation factor-like 11 | 0.072 | −0.22 | −0.017 | −0.65 | −0.13 | −0.76 |
| Scd1 | Stearoyl-CoA desaturase-1 | −0.54 | −0.30 | −0.007 | −1.35 | −1.20 | −1.95 |
| Mpeg1 | Macrophage expressed gene 1 | 0.0023 | −0.54 | −0.94 | 0.44 | 0.17 | −0.40 |
| Lrrc4c | Leucine rich repeat containing | −0.19 | −0.44 | −0.50 | 0.71 | 0.11 | −0.35 |
| Sfrp5 | Secreted frizzled-related protein 5 | 0.37 | −0.27 | −0.30 | −0.20 | 0.51 | 0.60 |
| Cav1 | Caveolin | −0.39 | 0.18 | 0.62 | 0.75 | −0.07 | 0.63 |
| Emr4 | Member of the EGF-TM7 family | 0.14 | −0.10 | 0.25 | 0.64 | 0.45 | 0.70 |
| Dlx2 | Distal-less homeobox 2 | −0.052 | 0.92 | 1.18 | 0.39 | 0.62 | 0.48 |
| Nmu | Neuromedin U | 0.074 | 0.44 | −0.062 | −0.50 | −0.41 | −0.24 |
| Cga | Choriogonadotropin alpha | 2.91 | 2.91 | 3.20 | 2.71 | 4.22 | 2.22 |
RNA sequencing was used to probe expression differences in brains in rats after 24 h of a single dose of analog. Expression data were analyzed using a general linear model to generate differential expression profiles utilizing a likelihood ratio test of significance of all coefficients. RXR, retinoid X receptor.