Table 1. Melting temperatures (ΔTm) of DNA G-quadruplex (KRAS21, HSP90) and duplex (T-Loop) structures stabilized by compounds 1a-d, 2a-d and TMPyP4 at 1 and 2 μM.

Comp.	ΔTm (°C) (a)
	KRAS21		HSP90A		T-Loop
	1 μM	2 μM	1 μM	2 μM	1 μM	2 μM
1a	8	12	14	20	<2	3
1b	5	10	12	16	<2	6
1c	<2	<2	4	7	<2	<2
1d	9	18	15	21	<2	10
2a	4	7	11	15	<2	<2
2b	10	16	14	19	3	6
2d	13	22	19	25	4	12
TMPyP4	25	n.d.	n.d.	n.d.	16	n.d.

^(a) standard deviation < 0.2°C;

n.d. = not determined.