Table 1. Demographics of cohort studies included in the meta-analysis.
| Author(year published) | Patients/n IBR/Control | Age, yearsIBR/Control | Region of study | Follow-up/mIBR/Control | Adjuvant treatments | Mastectomy type | Reconstruction type | Study Design |
|---|---|---|---|---|---|---|---|---|
| Noguchi[19] | 83/153 | 82/47.7 a | Japan | 41/58 | CT | MT | LDM, TRAM, | Retrospective cohort study |
| (1992) | Implant | |||||||
| Yoshimura[20] | 122/92 | 44/50 b | Japan | 78/55 | CT | NMT | NMT +Implant | Retrospective cohort study |
| (1996) | ||||||||
| Murphy[21] | 158/1262 | 48/66 b | USA | 75/75 | NA | MT | Implant, TRAM, | Retrospective cohort study |
| (2002) | LD+implant | |||||||
| Petit[22] | 518/159 | 69.3/22 a | Italy | 70/71 | CT, HT | MT | Implant, TRAM, | Retrospective cohort study |
| (2008) | LD+implant | |||||||
| Ueda[23] | 74/178 | 45.7/55 c | Japan | 50/54 | CT, HT, RT | MT | SMIBR+TRAM, | Prospective cohort study |
| (2008) | LD, Implant, DIEP | |||||||
| McCarthy[24] | 309/309 | 46.8/50.8 c | USA | 68.4/68.4 | CT, HT, RT | MT | Implant, tissue, | Retrospective cohort study (matched) |
| (2008) | expander | |||||||
| Gerber[25] | 108/130 | 47/58 b | Germany | 101/101 | CT, RT | MT | SMIBR+LD, | Historical prospective cohort study |
| (2009) | implant | |||||||
| Min [26] | 120/1699 | 40.7/47.6 b | Korea | 42.1/39.2 | CT, RT | BCS | LD | Retrospective cohort study |
| (2010) | ||||||||
| Lim[27] | 87/810 | 38.4/47.4 b | Korea | 62.5/65 | CT, HT, RT | MT | SMIBR+TRAM, | Retrospective cohort study (matched) |
| (2010) | LD, implant | |||||||
| Noguchi[19] | 83/153 | 82/47.7 a | Japan | 41/58 | CT | MT | LDM, TRAM, | Retrospective cohort study |
| (1992) | Implant | |||||||
| Yoshimura[20] | 122/92 | 44/50 b | Japan | 78/55 | CT | NMT | NMT +Implant | Retrospective cohort study |
| (1996) | ||||||||
| Murphy[21] | 158/1262 | 48/66 b | USA | 75/75 | NA | MT | Implant, TRAM, | Retrospective cohort study |
| (2002) | LD+implant | |||||||
| Petit[22] | 518/159 | 69.3/22 a | Italy | 70/71 | CT, HT | MT | Implant, TRAM, | Retrospective cohort study |
| (2008) | LD+implant | |||||||
| Ueda[23] | 74/178 | 45.7/55 c | Japan | 50/54 | CT, HT, RT | MT | SMIBR+TRAM, | Prospective cohort study |
| (2008) | LD, Implant, DIEP | |||||||
| McCarthy[24] | 309/309 | 46.8/50.8 c | USA | 68.4/68.4 | CT, HT, RT | MT | Implant, tissue, | Retrospective cohort study (matched) |
| (2008) | expander | |||||||
| Gerber[25] | 108/130 | 47/58 b | Germany | 101/101 | CT, RT | MT | SMIBR+LD, | Historical prospective cohort study |
| (2009) | implant | |||||||
| Min [26] | 120/1699 | 40.7/47.6 b | Korea | 42.1/39.2 | CT, RT | BCS | LD | Retrospective cohort study |
| (2010) | ||||||||
| Lim[27] | 87/810 | 38.4/47.4 b | Korea | 62.5/65 | CT, HT, RT | MT | SMIBR+TRAM, | Retrospective cohort study (matched) |
| (2010) | LD, implant | |||||||
| Eriksen[28] | 300/300 | 48/48 c | Sweden | 144/138 | CT, HT, RT | MT | implant | Retrospective cohort study |
| (2011) | ||||||||
| Nedumpara[29] | 135/452 | 47/59 c | England | 55/55 | CT, HT, RT | MT | LD, implant | Retrospective cohort study |
| (2011) | ||||||||
| Reddy[30] | 494/427 c | 47.8/56.4 c | USA | 54/54 | CT, HT, RT | MT | DIEP, LD, TRAM, SGAP, SIEA, implant | Retrospective cohort study |
| (2011) | ||||||||
| Lee[31] | 1000/3183 | 42.2/47.9 b | Korea | 56.4/60 | NA | MT | TRAM | Retrospective cohort study |
| (2012) | ||||||||
| Ota[32] | 133/308 | 46/58 c | Japan | 47/44 | CT, HT, RT | MT | TE | Prospective cohort study |
| (2014) |
a Percentage of patients younger than 50 years
b mean age
c median age.
N:number, m:months, BCS, breast conserving surgery, CT: chemotherapy, DIEP: deep inferior epigastric perforator, HT: hormonal therapy, IBR, immediate breast reconstruction, LD: latissimus dorsi, MT: mastectomy, RT: radiation therapy, S-GAP: superior Gluteus artery perforator, SIEA: superficial inferior epigastric artery flap, SMIBR: skin-sparing/nipple-sparing mastectomy and immediate breast reconstruction, TE: tissue expander, TRAM: transverse rectus abdominis musculocutaneous; NMT: nipple-preserving mastectomy