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. 2015 Feb 11;2:14068. doi: 10.1038/mtm.2014.68

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Copyright © 2015 American Society of Gene & Cell Therapy

This work is licensed under a Creative Commons Attribution-NonCommercial-NoDerivs 3.0 Unported License. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in the credit line; if the material is not included under the Creative Commons license, users will need to obtain permission from the license holder to reproduce the material. To view a copy of this license, visit http://creativecommons.org/licenses/by-nc-nd/3.0/

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Rotarod density plots show the relative likelihood that a mouse, based on age and genotype, will fall at a given time (seconds) versus the probability density function (“density”) which is determined by the distribution of the raw data. (a) Hets and NSGI mice at 2 months of age performed equally well in the rotarod test (P > 0.05). (b) A slight shift to the left is present for 4-month-old NSGIs indicating poorer performance compared to Hets (P < 0.05) and compared to 2-month-old NSGI (P < 0.05) while there is no change in 4-month-old Hets from the 2-month-old Het group (P > 0.05). (c) In 7-month-old NSGIs, the time of falling is extremely low (note the large shift to the left) while a large portion of the Het population can still complete testing to 330 seconds; the difference is highly significant (P < 0.001). The 7-month-old NSGI mice also performed worse than their 4-month-old counterparts (P < 0.001) while 7- and 4-month-old Hets had no statistical difference (P > 0.05). Each group has n = 8.