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. 2015 Feb 11;2:14068. doi: 10.1038/mtm.2014.68

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Copyright © 2015 American Society of Gene & Cell Therapy

This work is licensed under a Creative Commons Attribution-NonCommercial-NoDerivs 3.0 Unported License. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in the credit line; if the material is not included under the Creative Commons license, users will need to obtain permission from the license holder to reproduce the material. To view a copy of this license, visit http://creativecommons.org/licenses/by-nc-nd/3.0/

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NSGI mice show clear evidence of human hematopoietic stem cell engraftment. (a) Blood mononuclear cells isolated from transplanted mice were costained for human-specific and mouse-specific CD45 (hematopoietic specific leukocyte common antigen; hCD45 and mCD45, respectively) and showed a robust presence of human cells (circled). Co-staining for (b) hCD45 and CD20 showed the presence of B cells (circled) while costaining of (c) hCD45 and CD3 showed the presence of T cells (circled). (d,e) Human neural stem cells engraft widely throughout the NSGI brain. (d) Human specific nuclear antigen stained cells in cortex. (e) Human-specific nestin-positive cells (red) in the dentate gyrus of the NSG mouse brain 9 months after transplantation. Green GFAP-positive astrocytes are also seen. The scale bars are 25 µm.