Table 2. T. b. brucei TREU 927 ex vivo Langendorff parameters.
| ISO (μM) | Heart Rate (bpm)* | PR Interval (ms)* | QTc (Framingham (ms)) | ||||||
|---|---|---|---|---|---|---|---|---|---|
| Control (n = 5) | Infected(n = 5) | P value | Control (n = 5) | Infected(n = 5) | P value | Control (n = 5) | Infected (n = 5) | P value | |
| 0 | 280 ± 16 | 239 ± 11 | 0.073 | 37.4±3.2 | 39.1±1.7 | 0.665 | 203.3±4.9 | 187.8±12.0 | 0.265 |
| 0.1 | 317 ± 4 | 350 ± 31 | 0.321 | 31.1±2.2 | 37.1±4.3 | 0.245 | 206.3±3.2 | 194.2±2.2 | 0.015 |
| 1.0 | 336 ± 18 | 345 ± 23 | 0.780 | 30.0±2.0 | 37.5±1.9 | 0.028 | 206.5±2.8 | 202.8±2.8 | 0.451 |
| 10.0 | 319 ± 5 | 350 ± 14 | 0.073 | 31.1±2.3 | 38.3±3.5 | 0.118 | 209.1±4.3 | 206.8±2.4 | 0.655 |
| 100.0 | 328 ± 20 | 356 ± 19 | 0.334 | 33.2±3.4 | 39.5±3.9 | 0.252 | 209.5±4.4 | 211.9±2.8 | 0.657 |
*bpm; beats per minute, ms; milliseconds