Table 1.

Binding of the substituted quinolones 5–10 to BRD9 bromodomain as determined by DSF ΔT_m shift.

	Compound	R2	BRD9 ΔTm [°C][a]
	5		4.0±0.74 (4)
	6		5.9±0.48 (4)
	7		4.4±0.26 (4)
	8		2.5±0.35 (4)
	9		6.1±0.71 (4)
	10		1.6±0.49 (4)

[a] Mean ΔT_m±SEM (number of measurements). Compounds tested at 10 μm. SEM=standard error of the mean.