TABLE 1.
Sampling of Reported Retained Introns Some with Known Biological Function in Mammals
| Gene Name | Description | Intron | Reference |
|---|---|---|---|
| APP | Amyloid B-protein | I1, i2,i5, i6,i8, i13, i151 | 3 |
| ATF4 | Activating transcription factor 4 | i1 | 4 |
| CACNA1H | Calcium channel, voltage-dependent, T type, α 1H subunit | i23 | 5 |
| CAMK2B | Calcium/calmodulin-dependent protein kinase II β | i3 | 3 |
| CTSD | Cathepsin D | i5 | 4 |
| CREB | cAMP response element binding protein | i1 | 3 |
| EIF1 | Eukaryotic translation initiation factor 1 | i1 | 4 |
| FMR1 | Fragile X mental retardation 1 | i1 | 3 |
| FANCA | Fanconi anemia, complementation group A | i21 | 4 |
| GABRG3 | γ-Aminobutyric acid (GABA) A receptor, γ | ||
| GRIK1 | Glutamate receptor, ionotropic, kainate 1 | i1, i7 | 3 |
| GRIN1 | NMDA 1 receptor | i8 | 3 |
| HP | Haptoglobin | i4 | 4 |
| ID3 | Inhibitor of DNA binding 3, dominant negative helix-loop-helix protein | i1 | 6 |
| IL1B | Interleukin 1, β | i1 | 7 |
| INS | Proinsulin | i1 | 8 |
| KCNMA1 | Potassium large conductance calcium-activated channel, subfamily M, α member 1 | i16 | 9 |
| KCNMA1 | Potassium large conductance calcium-activated channel, subfamily M, α member 1 | i17 | 10 |
| LBR | Lamin B receptor | i9 | 4 |
| LMNB1 | Lamin B1 | i7 | 4 |
| P2X2 | Purinergic receptor P2X, ligand-gated ion channel, 2 | i11 | 11 |
| Robo3 | Roundabout, axon guidance receptor, homolog 3 (Drosophila) | i26 | 12 |
| SRSF7 | Serine/arginine-rich splicing factor 7 (reported as 9G8) | i3 | 13 |
1
In instances where more than one retained intron is indicated for a given gene name, the retained introns need not all be present in a single CIRT. The retained introns may be found in different RNA molecules, each of which has been detected by sequencing.