Table 3. Meta-analysis results for OS and DFS.
| Analysis | OS | DFS | ||||||||
|---|---|---|---|---|---|---|---|---|---|---|
| N | HR(95% CI) | I2 | Ph | P | N | HR(95% CI) | I2 | Ph | P | |
| 16 | 1.809(1.442–2.270) | 63.3% | <0.001 | <0.001 | 5 | 1.481(1.028–2.133) | 71.4% | 0.007 | 0.035 | |
| Subgroup1: digestive tract | 12 | 1.875(1.426–2.464) | 66.5% | 0.001 | <0.001 | |||||
| Digestive gland | 4 | 1.636(1.056–2.536) | 57.4% | 0.070 | 0.028 | |||||
| Subgroup2: surgery | 13 | 1.871(1.425–2.458) | 65.0% | 0.052 | <0.001 | |||||
| Non-surgical | 2 | 1.361(0.640–2.895) | 73.4% | 0.001 | 0.423 | |||||
| Subgroup3: Caucasian | 5 | 1.656(1.067–2.571) | 72.8% | 0.005 | 0.025 | |||||
| Asian | 11 | 1.873(1.415–2.481) | 61.7% | 0.004 | <0.001 | |||||
| Subgroup4: E | 8 | 1.490(1.101–2.016) | 60.0% | 0.015 | 0.010 | |||||
| I | 1 | 1.610(1.109–2.338) | - | - | 0.012 | |||||
| EI | 7 | 2.430(1.622–3.641) | 66.7% | 0.006 | <0.001 | |||||
| Subgroup5: Sample size≥200 | 4 | 1.846(1.542–2.209) | 0 | 0.416 | <0.001 | |||||
| Sample size<200 | 12 | 1.818(1.276–2.591) | 70.9% | <0.001 | 0.001 | |||||
| Subgroup6: Rabbit pAb | 11 | 1.918(1.394–2.640) | 69.0% | <0.001 | <0.001 | |||||
| others | 3 | 1.947(1.448–2.617) | 0 | 0.392 | <0.001 | |||||
Ph: p value of Q test for heterogeneity test; N: number of studies (cohorts); HR: hazard ratio; 95% CI: 95% confidence interval; OS: overall survival; DFS: progression-free survival; E: extent; I: intensity; Rabbit pAb: rabbit polyclonal antibody