Table 3. Simple correlation and multivariate regression analyses on change in urinary albumin-creatinine ratio.

	Crude		Model 1		Model 2
Men	r	P	ß	P	ß	P
Age	0.070	0.267	0.012	0.862	0.014	0.842
Duration of diabetes	0.020	0.752	-0.034	0.540	0.004	0.949
Body mass index	0.030	0.633	0.024	0.722	0.037	0.611
Systolic blood pressure	0.164	0.009	0.148	0.019	0.133	0.039
Hemoglobin	-0.198	0.002	-0.254	0.0002	-0.259	0.0002
Hemoglobin A1c	0.151	0.016	0.176	0.007	0.202	0.003
Total cholesterol	-0.002	0.973	_	_	-0.004	0.954
Logarithm of triglycerides	0.031	0.624	_	_	0.001	0.989
Uric acid	0.066	0.298	_	_	0.085	0.196
Creatinine	0.054	0.395	_	_	0.019	0.780
Smoking status	_	_	_	_	0.010	0.874
RAS inhibitors	_	_	_	_	-0.012	0.859
Statin	_	_	_	_	-0.117	0.080
Women	r	P	ß	P	ß	P
Age	0.144	0.074	0.058	0.402	0.020	0.816
Duration of diabetes	0.269	0.0007	-0.040	0.545	0.128	0.135
Body mass index	0.228	0.005	0.083	0.211	0.233	0.004
Systolic blood pressure	0.304	0.0001	0.101	0.110	0.221	0.006
Hemoglobin	-0.276	0.0005	-0.230	0.0007	-0.194	0.030
Hemoglobin A1c	0.267	0.0008	0.134	0.035	0.175	0.040
Total cholesterol	-0.068	0.402	_	_	-0.025	0.774
Logarithm of triglycerides	-0.007	0.935	_	_	-0.008	0.925
Uric acid	0.077	0.345	_	_	0.034	0.715
Creatinine	0.138	0.089	_	_	0.024	0.793
Smoking status	_	_	_	_	-0.036	0.645
RAS inhibitors	_	_	_	_	-0.128	0.099
Statin	_	_	_	_	0.061	0.467

RAS, rennin-angiotensin system; Model 1 is adjusted for age, duration of diabetes, body mass index, systolic blood pressure, hemoglobin and hemoglobin A1c. Model 2 includes all variables in Model 1 plus total cholesterol, logarithm of triglycerides, uric acid, creatinine, smoking status, the use of rennin-angiotensin system inhibitors and the use of statin. Smoking status was defined as nonsmoker (= 0), previous smoker (= 1), or current smoker (= 2), and the use of rennin-angiotensin system inhibitors or statin was defined as without (= 0) or with (= 1).