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. 2015 May 29;10(5):e0127899. doi: 10.1371/journal.pone.0127899

Fig 4. Frequency of LMP1- or LMP2a-specific CD8+ and CD4+ T cell responses of healthy Korean donors.

Fig 4

Monocyte-derived DCs isolated from peripheral blood mononuclear cells (PBMCs) from EBV-seropositive (n = 23) and EBV-seronegative (n = 4) healthy donors were evaluated in response to mRNAs for latent (LMP1 and LMP2a) EBV antigens. Results are shown as IFN-γ secreting T cell number/5 × 105 for IFN-γ ELISPOT responses. EBV-specific CD4+ T cell responses determined by the LMP1 ELISPOT assay are significantly higher than those detected by the LMP2a ELISPOT assay (p = 0.0067, two-tailed Mann-Whitney test). Box and whisker plots (Tukey’s test; 25% ~ 75%) indicate median (middle line in the box) of EBV-specific T cell responses in individuals.