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. 2015 May 29;10(5):e0127549. doi: 10.1371/journal.pone.0127549

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© 2015 Lev et al

This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are properly credited.

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Fig 5 — C57/bl6 mice were injected with FITC-Albumin (FITC-Alb) to visualize intact blood vessels. FITC conjugated TAT peptide (FITC-TAT), FITC conjugated ND-13 lacking the TAT sequence (ND-13C-FITC) or FITC conjugated full length ND-13 (ND-13-FITC) were injected subcutaneous (SC) and monitored by CellVizio system for additional 30 min. Time dependent accumulation of the fluorescent signal in the brain parenchyma around the blood vessels was observed when mice were administrated with either TAT-FITC or ND-13-FITC but not with ND-13C, indicating that the TAT-derived cell penetrating peptide enables ND-13 to penetrate the BBB.