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. 2015 May 29;10(5):e0127549. doi: 10.1371/journal.pone.0127549

Fig 10. Subcutaneous ND-13 administration preserves dopamine levels in MPTP treated mice.

Fig 10

(A) Systemic MPTP injection (25mg/kg) for 5 consecutive days reduced dopamine levels in the brain by selectivetoxicity to dopaminergic cells. Subcutaneous injection of ND-13 (20mg/Kg daily) restored dopamine levels, as measured by HPLC (* p<0.05). (B) Mean intensity of tyrosine hydroxylase immune reactivity area measured in the substantia nigra. Immunohistochemistry of the substantia nigra for tyrosine hydroxylase staining in vehicle-treated mice (C), MPTP-treated mice (D), and ND-13-treated MPTP mice (E). Reduced TH labeling is shown in vehicle-treated MPTP substantia nigra. ND-13 treatment partially restores tyrosine hydroxylase staining. Scale bar = 100 μm.