Table 4. Results of the meta-analysis of the relationship of TLR2 and TLR4 polymorphism with CD or UC risk.
Study | Genetic model | OR | 95% CI | I2(%) | P value | No. of study | Egger |
---|---|---|---|---|---|---|---|
TLR2 677 vs CD | dominant model | 3.54 | 0.71–17.71 | 0.00 | 0.99 | 6 | / |
additive model | 3.54 | 0.71–17.71 | 0.00 | 0.99 | 6 | / | |
recessive model | 3.54 | 0.71–17.71 | 0.00 | 0.99 | 6 | / | |
TLR2 677 vs UC | dominant model | 1.93 | 0.39–9.59 | 0.00 | 1.00 | 6 | / |
additive model | 1.93 | 0.39–9.59 | 0.00 | 1.00 | 6 | / | |
recessive model | 1.93 | 0.39–9.59 | 0.00 | 1.00 | 6 | / | |
TLR2 753 vs CD | dominant model | 0.84 | 0.53–1.33 | 0.00 | 0.84 | 9 | / |
allele model | 2.69 | 0.77–9.44 | 0.00 | 1.00 | 9 | / | |
TLR2 753 vs UC | dominant model | 1.14 | 0.63–2.05 | 0.00 | 1.00 | 8 | / |
allele model | 1.14 | 0.63–2.05 | 0.00 | 1.00 | 8 | / | |
TLR4 299 vs CD | dominant model | 1.44 | 1.27–1.63 | 20.50 | 0.15 | 33 | 0.50 |
additive model | 1.62 | 0.98–2.67 | 0.00 | 1.00 | 32 | 0.39 | |
recessive model | 1.82 | 1.11–3.01 | 0.00 | 1.00 | 32 | 0.74 | |
allele model | 1.40 | 1.24–1.57 | 25.00 | 0.10 | 33 | 0.49 | |
TLR4 299 vs UC | dominant model | 1.50 | 1.28–1.76 | 44.90 | 0.01 | 26 | 0.82 |
additive model | 2.37 | 1.29–4.35 | 0.00 | 1.00 | 26 | 0.97 | |
recessive model | 2.25 | 1.22–4.12 | 0.00 | 1.00 | 26 | 0.91 | |
allele model | 1.40 | 1.22–1.62 | 43.60 | 0.01 | 27 | 0.62 | |
TLR4 399 vs CD | dominant model | 1.26 | 1.03–1.54 | 0.00 | 0.97 | 16 | 0.04 |
additive model | 1.45 | 0.66–3.18 | 0.00 | 0.98 | 16 | 0.59 | |
recessive model | 1.35 | 0.62–2.95 | 0.00 | 0.98 | 16 | 0.41 | |
allele model | 1.21 | 1.01–1.44 | 0.00 | 0.95 | 17 | 0.10 | |
TLR4 399 vs UC | dominant model | 1.41 | 1.09–1.82 | 0.00 | 0.61 | 13 | 0.56 |
additive model | 1.89 | 0.70–5.13 | 0.00 | 1.00 | 13 | 0.74 | |
recessive model | 1.84 | 0.68–5.00 | 0.00 | 1.00 | 13 | 0.65 | |
allele model | 1.26 | 1.02–1.56 | 0.00 | 0.52 | 14 | 0.36 | |
High quality studies | |||||||
TLR4 299 vs CD | dominant model | 1.56 | 1.35–1.80 | 3.00 | 0.42 | 26 | 0.47 |
additive model | 1.72 | 0.98–3.02 | 0.00 | 1.00 | 25 | 0.44 | |
recessive | 1.94 | 1.10–3.40 | 0.00 | 1.00 | 25 | 0.60 | |
allele model | 1.50 | 1.31–1.72 | 12.20 | 0.29 | 26 | 0.47 | |
TLR4 299 vs UC | dominant model | 1.55 | 1.28–1.87 | 49.10 | 0.01 | 20 | 0.66 |
additive model | 2.49 | 1.25–4.95 | 0.00 | 0.99 | 20 | 0.97 | |
recessive | 2.35 | 1.18–4.67 | 0.00 | 0.99 | 20 | 0.88 | |
allele model | 1.51 | 1.16–1.98 | 47.10 | 0.01 | 21 | 0.46 | |
TLR4 399 vs CD | dominant model | 1.16 | 0.92–1.46 | 0.00 | 0.98 | 13 | 0.03 |
additive model | 1.50 | 0.65–3.46 | 0.00 | 0.92 | 13 | 0.53 | |
recessive | 1.40 | 0.61–3.21 | 0.00 | 0.92 | 13 | 0.37 | |
allele model | 1.13 | 0.93–1.37 | 0.00 | 0.96 | 14 | 0.14 | |
TLR4 399 vs UC | dominant model | 1.32 | 1.00–1.75 | 0.00 | 0.78 | 11 | 0.38 |
additive model | 1.65 | 0.55–4.90 | 0.00 | 1.00 | 11 | 0.43 | |
recessive | 1.62 | 0.54–4.81 | 0.00 | 1.00 | 11 | 0.41 | |
allele model | 1.19 | 0.95–1.49 | 0.00 | 0.76 | 12 | 0.24 | |
Group by ethinicity | |||||||
TLR2 753 vs CD | |||||||
Asia | dominant model | 3.54 | 0.71–17.71 | 0.00 | 0.99 | 6 | / |
allele model | 3.54 | 0.71–17.71 | 0.00 | 0.99 | 6 | / | |
Caucasian | dominant model | 0.73 | 0.36–1.47 | 0.00 | 0.48 | 2 | / |
allele model | 1.05 | 0.07–16.82 | 0.00 | 0.99 | 2 | / | |
TLR2 753 vs UC | |||||||
Asian | dominant model | 1.93 | 0.39–9.59 | 0.00 | 1.00 | 6 | / |
allele model | 1.93 | 0.39–9.59 | 0.00 | 1.00 | 6 | / | |
Caucasian | dominant model | 1.05 | 0.56–1.97 | 0.00 | 0.77 | 2 | / |
allele model | 1.50 | 0.09–24.07 | 0.00 | 0.87 | 2 | / | |
TLR4 299 vs CD | |||||||
Asian | dominant model | 2.17 | 0.52–9.14 | 0.00 | 0.92 | 7 | / |
additive model | 2.17 | 0.52–9.14 | 0.00 | 0.92 | 7 | / | |
recessive | 2.17 | 0.52–9.14 | 0.92 | 7 | / | ||
allele model | 1.87 | 0.45–7.74 | 0.00 | 0.80 | 7 | / | |
Caucasian | dominant model | 1.45 | 1.28–1.64 | 37.90 | 0.04 | 23 | / |
additive model | 1.72 | 1.00–2.96 | 0.00 | 1.00 | 23 | / | |
recessive | 1.74 | 1.01–2.99 | 0.00 | 1.00 | 23 | / | |
allele model | 1.43 | 1.26–1.62 | 42.50 | 0.02 | 22 | / | |
Others | dominant model | 0.99 | 0.46–2.10 | 0.00 | 0.46 | 3 | / |
additive model | 0.98 | 0.10–9.61 | 0.00 | 1.00 | 3 | / | |
recessive | 2.17 | 0.22–21.12 | 0.00 | 0.57 | 3 | / | |
allele model | 1.14 | 0.78–1.66 | 0.00 | 0.64 | 4 | / | |
TLR4 299 vs UC | |||||||
Asian | dominant model | 1.86 | 0.46–7.46 | 0.00 | 1.00 | 8 | / |
additive model | 1.86 | 0.46–7.46 | 0.00 | 1.00 | 8 | / | |
recessive | 1.86 | 0.46–7.46 | 0.00 | 1.00 | 8 | / | |
allele model | 1.86 | 0.46–7.46 | 0.00 | 1.00 | 8 | / | |
Caucasian | dominant model | 1.51 | 1.01–2.07 | 67.90 | 0.00 | 15 | 0.93 |
additive model | 2.14 | 1.04–4.39 | 0.00 | 0.98 | 15 | 0.86 | |
recessive | 1.99 | 0.97–4.08 | 0.00 | 0.99 | 15 | 0.82 | |
allele model | 1.48 | 1.11–1.96 | 64.10 | 0.00 | 15 | 0.94 | |
Others | dominant model | 1.73 | 1.04–2.88 | 0.00 | 0.55 | 3 | / |
additive model | 8.10 | 1.17–55.93 | 0.80 | 0.37 | 3 | / | |
recessive | 7.74 | 1.12–53.40 | 4.90 | 0.35 | 3 | / | |
allele model | 1.20 | 0.88–1.64 | 47.60 | 0.13 | 4 | / | |
TLR4 399 vs CD | |||||||
Asian | dominant model | 3.54 | 0.71–17.71 | 0.00 | 1.00 | 6 | / |
additive model | 3.54 | 0.71–17.71 | 0.00 | 1.00 | 6 | / | |
recessive | 3.54 | 0.71–17.71 | 0.00 | 1.00 | 6 | / | |
allele model | 3.57 | 0.72–17.75 | 0.00 | 1.00 | 6 | / | |
Caucasian | dominant model | 1.20 | 0.97–1.49 | 0.00 | 0.78 | 8 | / |
additive model | 0.98 | 0.30–3.21 | 0.00 | 0.78 | 8 | / | |
recessive | 0.96 | 0.29–3.14 | 0.00 | 0.78 | 8 | / | |
allele model | 1.19 | 0.96–1.46 | 0.00 | 0.62 | 8 | / | |
Others | dominant model | 1.58 | 0.85–2.93 | 0.00 | 0.91 | 2 | / |
additive model | 1.28 | 0.32–5.11 | 0.00 | 0.87 | 2 | / | |
recessive | 1.07 | 0.28–4.16 | 0.00 | 0.92 | 2 | / | |
allele model | 1.20 | 0.85–1.69 | 0.00 | 0.70 | 3 | / | |
TLR4 399 vs UC | |||||||
Asian | dominant model | 1.93 | 0.39–9.59 | 0.00 | 1.00 | 6 | / |
additive model | 1.93 | 0.39–9.59 | 0.00 | 1.00 | 6 | / | |
recessive | 1.93 | 0.39–9.59 | 0.00 | 1.00 | 6 | / | |
allele model | 1.93 | 0.39–9.59 | 0.00 | 1.00 | 7 | / | |
Caucasian | dominant model | 1.42 | 1.09–1.85 | 43.70 | 0.11 | 6 | / |
additive model | 1.80 | 0.47–6.92 | 0.00 | 0.85 | 6 | / | |
recessive | 1.71 | 0.44–6.59 | 0.00 | 0.84 | 6 | / | |
allele model | 1.42 | 1.11–1.83 | 38.10 | 0.15 | 6 | / | |
Others | allele model | 0.91 | 0.62–1.35 | 0.00 | 0.67 | 2 | / |