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. 2015 May 29;10(5):e0126803. doi: 10.1371/journal.pone.0126803

Table 4. Results of the meta-analysis of the relationship of TLR2 and TLR4 polymorphism with CD or UC risk.

Study Genetic model OR 95% CI I2(%) P value No. of study Egger
TLR2 677 vs CD dominant model 3.54 0.71–17.71 0.00 0.99 6 /
additive model 3.54 0.71–17.71 0.00 0.99 6 /
recessive model 3.54 0.71–17.71 0.00 0.99 6 /
TLR2 677 vs UC dominant model 1.93 0.39–9.59 0.00 1.00 6 /
additive model 1.93 0.39–9.59 0.00 1.00 6 /
recessive model 1.93 0.39–9.59 0.00 1.00 6 /
TLR2 753 vs CD dominant model 0.84 0.53–1.33 0.00 0.84 9 /
allele model 2.69 0.77–9.44 0.00 1.00 9 /
TLR2 753 vs UC dominant model 1.14 0.63–2.05 0.00 1.00 8 /
allele model 1.14 0.63–2.05 0.00 1.00 8 /
TLR4 299 vs CD dominant model 1.44 1.27–1.63 20.50 0.15 33 0.50
additive model 1.62 0.98–2.67 0.00 1.00 32 0.39
recessive model 1.82 1.11–3.01 0.00 1.00 32 0.74
allele model 1.40 1.24–1.57 25.00 0.10 33 0.49
TLR4 299 vs UC dominant model 1.50 1.28–1.76 44.90 0.01 26 0.82
additive model 2.37 1.29–4.35 0.00 1.00 26 0.97
recessive model 2.25 1.22–4.12 0.00 1.00 26 0.91
allele model 1.40 1.22–1.62 43.60 0.01 27 0.62
TLR4 399 vs CD dominant model 1.26 1.03–1.54 0.00 0.97 16 0.04
additive model 1.45 0.66–3.18 0.00 0.98 16 0.59
recessive model 1.35 0.62–2.95 0.00 0.98 16 0.41
allele model 1.21 1.01–1.44 0.00 0.95 17 0.10
TLR4 399 vs UC dominant model 1.41 1.09–1.82 0.00 0.61 13 0.56
additive model 1.89 0.70–5.13 0.00 1.00 13 0.74
recessive model 1.84 0.68–5.00 0.00 1.00 13 0.65
allele model 1.26 1.02–1.56 0.00 0.52 14 0.36
High quality studies
TLR4 299 vs CD dominant model 1.56 1.35–1.80 3.00 0.42 26 0.47
additive model 1.72 0.98–3.02 0.00 1.00 25 0.44
recessive 1.94 1.10–3.40 0.00 1.00 25 0.60
allele model 1.50 1.31–1.72 12.20 0.29 26 0.47
TLR4 299 vs UC dominant model 1.55 1.28–1.87 49.10 0.01 20 0.66
additive model 2.49 1.25–4.95 0.00 0.99 20 0.97
recessive 2.35 1.18–4.67 0.00 0.99 20 0.88
allele model 1.51 1.16–1.98 47.10 0.01 21 0.46
TLR4 399 vs CD dominant model 1.16 0.92–1.46 0.00 0.98 13 0.03
additive model 1.50 0.65–3.46 0.00 0.92 13 0.53
recessive 1.40 0.61–3.21 0.00 0.92 13 0.37
allele model 1.13 0.93–1.37 0.00 0.96 14 0.14
TLR4 399 vs UC dominant model 1.32 1.00–1.75 0.00 0.78 11 0.38
additive model 1.65 0.55–4.90 0.00 1.00 11 0.43
recessive 1.62 0.54–4.81 0.00 1.00 11 0.41
allele model 1.19 0.95–1.49 0.00 0.76 12 0.24
Group by ethinicity
TLR2 753 vs CD
Asia dominant model 3.54 0.71–17.71 0.00 0.99 6 /
allele model 3.54 0.71–17.71 0.00 0.99 6 /
Caucasian dominant model 0.73 0.36–1.47 0.00 0.48 2 /
allele model 1.05 0.07–16.82 0.00 0.99 2 /
TLR2 753 vs UC
Asian dominant model 1.93 0.39–9.59 0.00 1.00 6 /
allele model 1.93 0.39–9.59 0.00 1.00 6 /
Caucasian dominant model 1.05 0.56–1.97 0.00 0.77 2 /
allele model 1.50 0.09–24.07 0.00 0.87 2 /
TLR4 299 vs CD
Asian dominant model 2.17 0.52–9.14 0.00 0.92 7 /
additive model 2.17 0.52–9.14 0.00 0.92 7 /
recessive 2.17 0.52–9.14 0.92 7 /
allele model 1.87 0.45–7.74 0.00 0.80 7 /
Caucasian dominant model 1.45 1.28–1.64 37.90 0.04 23 /
additive model 1.72 1.00–2.96 0.00 1.00 23 /
recessive 1.74 1.01–2.99 0.00 1.00 23 /
allele model 1.43 1.26–1.62 42.50 0.02 22 /
Others dominant model 0.99 0.46–2.10 0.00 0.46 3 /
additive model 0.98 0.10–9.61 0.00 1.00 3 /
recessive 2.17 0.22–21.12 0.00 0.57 3 /
allele model 1.14 0.78–1.66 0.00 0.64 4 /
TLR4 299 vs UC
Asian dominant model 1.86 0.46–7.46 0.00 1.00 8 /
additive model 1.86 0.46–7.46 0.00 1.00 8 /
recessive 1.86 0.46–7.46 0.00 1.00 8 /
allele model 1.86 0.46–7.46 0.00 1.00 8 /
Caucasian dominant model 1.51 1.01–2.07 67.90 0.00 15 0.93
additive model 2.14 1.04–4.39 0.00 0.98 15 0.86
recessive 1.99 0.97–4.08 0.00 0.99 15 0.82
allele model 1.48 1.11–1.96 64.10 0.00 15 0.94
Others dominant model 1.73 1.04–2.88 0.00 0.55 3 /
additive model 8.10 1.17–55.93 0.80 0.37 3 /
recessive 7.74 1.12–53.40 4.90 0.35 3 /
allele model 1.20 0.88–1.64 47.60 0.13 4 /
TLR4 399 vs CD
Asian dominant model 3.54 0.71–17.71 0.00 1.00 6 /
additive model 3.54 0.71–17.71 0.00 1.00 6 /
recessive 3.54 0.71–17.71 0.00 1.00 6 /
allele model 3.57 0.72–17.75 0.00 1.00 6 /
Caucasian dominant model 1.20 0.97–1.49 0.00 0.78 8 /
additive model 0.98 0.30–3.21 0.00 0.78 8 /
recessive 0.96 0.29–3.14 0.00 0.78 8 /
allele model 1.19 0.96–1.46 0.00 0.62 8 /
Others dominant model 1.58 0.85–2.93 0.00 0.91 2 /
additive model 1.28 0.32–5.11 0.00 0.87 2 /
recessive 1.07 0.28–4.16 0.00 0.92 2 /
allele model 1.20 0.85–1.69 0.00 0.70 3 /
TLR4 399 vs UC
Asian dominant model 1.93 0.39–9.59 0.00 1.00 6 /
additive model 1.93 0.39–9.59 0.00 1.00 6 /
recessive 1.93 0.39–9.59 0.00 1.00 6 /
allele model 1.93 0.39–9.59 0.00 1.00 7 /
Caucasian dominant model 1.42 1.09–1.85 43.70 0.11 6 /
additive model 1.80 0.47–6.92 0.00 0.85 6 /
recessive 1.71 0.44–6.59 0.00 0.84 6 /
allele model 1.42 1.11–1.83 38.10 0.15 6 /
Others allele model 0.91 0.62–1.35 0.00 0.67 2 /