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. 2015 May 29;10(5):e0128078. doi: 10.1371/journal.pone.0128078

Fig 2. hUCB-MSC-CM inhibits tyrosinase activity and down-regulates melanogenic enzymes in melanocytes.

Fig 2

(A, B) Melan-a cells pre-treated with α-MSH (1 μM) were incubated with conditioned medium derived from hUCB-MSCs (UCB #1, #2) or treated resveratrol (RSV) (100 μM) for 24 hr. Then, the cells were harvested to measure the tyrosinase activity (A). Expressional level of tyrosinase and TRP1 proteins was analyzed by Western blotting (B). Data represent ± standard error of the mean (S.E.M.) from more than three independent experiments, n = 3,* p<0.02).