Figure 6.

Ca²⁺-activated Cl⁻ currents triggered by Ca²⁺ entry through voltage-gated Ca²⁺ channels in rat pulmonary artery smooth muscle cells (PASMCs). A, Typical family of whole-cell currents (top traces) recorded from a single PASMC with the voltage-clamp protocol shown below the traces. The cell was bathed in a solution containing 1.8 mM Ca²⁺. B, Mean current-voltage relationships for currents measured as indicated in A and labeled as the early transient current (I_tr) measured between 50 and 90 ms, the time-dependent current (I_td) measured at the end of the depolarizing step (between 750 and 790 ms), and the tail current (I_tail) measured immediately after repolarization to the holding potential of −70 mV (between 900 and 940 ms). Each data point represents a mean ± SEM (n = 13). Reproduced from Yuan⁴¹ with permission from the American Physiological Society.