Table 2.
Associated comorbidities in pulmonary hypertension–related hospitalizations
| 2000 | 2003 | 2006 | 2009 | Pa | |
|---|---|---|---|---|---|
| CHD | 49.8 (48.8–50.4) | 52.6 (52.0–53.0) | 47.9 (47.4–48.3) | 52.8 (52.5–52.9) | 0.025 |
| BPD | 4.2 (3.9–4.4) | 8.6 (8.3–8.8) | 10.5 (9.7–11.1) | 13.7 (13.2–14.0) | <0.001 |
| CDH | 2.4 (1.8–3.0) | 1.7 (1.3–2.1) | 1.7 (9.7–11.1) | 1.9 (1.5–2.3) | 0.1868 |
| Chromosomal abnormalities | 15.5 (13.8–17.2) | 19.0 (16.8–21.2) | 17.6 (15.6–19.6) | 17.6 (15.8–19.4) | 0.0561 |
| SLE/CTD | 1.4 (0.8–1.7) | 1.4 (1.2–1.5) | 1.8 (1.1–2.3) | 1.8 (1.5–2.1) | …b |
| SCD | 1.6 (0.9–2.0) | 2.8 (1.9–3.4) | 3.5 (3.2–3.6) | 5.1 (4.2–5.7) | …b |
| Sepsis | 7.6 (7.4–7.7) | 10.4 (10.0–10.6) | 11.8 (11.7–11.9) | 13.3 (13.2–13.4) | <0.001 |
| Respiratory failure | 8.6 (7.9–9.0) | 11.7 (11.4–11.9) | 13.0 (12.3–13.5) | 19.2 (18.4–19.8) | <0.001 |
| Acute renal failure | 1.8 (1.5–2.0) | 1.7 (1.5–1.8) | 2.4 (2.3–2.5) | 3.7 (3.5–3.9) | <0.001 |
| ECMO | 2.3 (1.6–2.8) | 1.4 (1.2–1.6) | 1.5 (1.3–1.7) | 2.0 (1.8–2.2) | 0.045 |
| Hepatic insufficiency | 1.5 (1.2–1.6) | 2.0 (1.7–2.2) | 2.2 (2.0–2.3) | 2.9 (2.8–3.1) | 0.003 |
| Arrhythmias | 8.5 (7.9–8.9) | 9.4 (9.3–9.6) | 10.0 (9.7–10.2) | 12.7 (12.5–12.8) | 0.001 |
| Cardiomyopathy | 5.1 (4.9–5.3) | 5.4 (5.1–5.7) | 4.2 (3.9–4.4) | 4.4 (4.2–4.6) | 0.016 |
Note
Data are percent of hospitalizations (95% confidence interval). BPD: bronchopulmonary dysplasia; CDH: congenital diaphragmatic hernia; CHD: congenital heart disease; CTD: connective tissue disease; ECMO: extracorporeal membrane oxygenation; PH: pulmonary hypertension; SCD: sickle cell disease; SLE: systemic lupus erythematosus.
a
Comparing associated comorbidities across years.
b
P value could not be calculated because of rarity of the event.