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. Author manuscript; available in PMC: 2015 Jul 15.
Published in final edited form as: Cell. 2014 Dec 31;160(0):191–203. doi: 10.1016/j.cell.2014.11.041

Figure 3. Inverse Correlation between Sequence Affinity and Specificity.

Figure 3

The proportion of 12mer sequences bound by various Hox-Exd complexes versus relative affinity of these 12mers for Ubx/AbdA-Exd is shown as colored bars (specificity groups). The number of 12mers in each affinity bin is plotted as a gray line. Average relative affinities of 12mers were calculated for four pairs of Hox-Exd complexes with similar binding profiles: (1) Labial and Pb, (2) Dfd and Scr, (3) AbdB and Antp, and (4) Ubx and AbdA. Sequences specific for Ubx/AbdA-Exd (green bars) are more prevalent in lower affinity bins than in higher affinity bins.