Fig. 3.

Periodic stimulation parameters modulate calcium response fidelity of a cell population with cell-to-cell variability. A) Increasing the stimulant concentration (C) increases the calcium response fidelity; parameters ‘D’ and ‘R’ were both fixed at 24 s. B) Increasing the stimulation duration (D) increases the calcium response fidelity; parameters ‘C’ and ‘R’ were fixed at 10 nM and 24 s, respectively. C) Increasing the rest period (R) increased the calcium response fidelity; ‘C’ and ‘D’ were fixed at 10 nM and 24 s, respectively. Bars represent the standard deviation. All conditions were statistically significant based upon the Student T-test, with p < 0.05.