Table 2.
hUC-MSC transplantation for treating rat bone nonunion; biomechanical study on the correlation with AKT
| Fracture group | hUC-MSCs + blood plasma | hUC-MSCs + blood plasma + AKT blocker | p value | |
|---|---|---|---|---|
| Bending stress value at the maximum bending load (MPa) | 525.14 ± 65.36 | 84.69 ± 32.17 | 49.99 ± 16.21*△ | <0.05 |
| The bending strain in the maximum bending load (%) | 11.70 ± 3.22 | 20.73 ± 6.51 | 31.66 ± 5.47*△ | <0.05 |
| Geometry | Round | Round | Round | |
| Pivot span (mm) | 10.00 | 10.00 | 10.00 | |
| Diameter (mm) | 2.00 | 3.00 | 4.00 | |
| Speed (mm/min) | 2.00 | 2.00 | 2.00 | |
| The bending displacement in the maximum bending load (mm) | 0.97 ± 0.26 | 1.15 ± 0.31 | 1.32 ± 0.53*△ | <0.05 |
| The maximum bending load (N) | 164.98 ± 23.55 | 89.79 ± 19.76 | 125.65 ± 21.42*△ | <0.05 |
| Modulus of elasticity (Automatic Young’s) (MPa) | 15903.14 ± 366.79 | 2253.54 ± 121.66 | 589.24 ± 116.34*△ | <0.01 |
*p: The values of hUC-MSCs + blood plasma + AKT blocker compared to these of fracture group; △ p: The values of hUC-MSCs + blood plasma + AKT blocker compared tothese of fracture group