. 2015 May 14;35(6):375–384. doi: 10.1007/s40261-015-0291-9

Table 4.

Fidaxomicin and OP-1118 fecal pharmacokinetic parameters at Day 1 after single dose

Compound	Parameter	Japanese 100 mg		Japanese 200 mg		Caucasian 200 mg
Compound	Parameter	Ae_last (mg)	%Ae_last (%)	Ae_last (mg)	%Ae_last (%)	Ae_last (mg)	%Ae_last (%)
Fidaxomicin	n	9	9	9	9	9	9
	Mean ± SD	28.72 ± 17.72	28.72 ± 17.72	72.66 ± 58.38	36.33 ± 29.19	77.86 ± 47.05	38.93 ± 23.53
	Median	28.85	28.85	103.5	51.76	86.86	43.43
	Min–max	0^a–67.4	0^a–67.4	0^a–149	0^a–74.7	0^a–143	0^a–71.3
OP-1118	n	9	9	9	9	9	9
	Mean ± SD	23.14 ± 13.18	24.78 ± 14.11	34.64 ± 28.29	18.55 ± 15.15	43.56 ± 20.84	23.32 ± 11.16
	Median	23.89	25.59	41.98	22.48	43.08	23.07
	Min–max	0^b–40.8	0^b–43.7	0^b–75.3	0^b–40.3	0^b–73.9	0^b–39.6

Ae _last cumulative amount of drug excreted in the feces from time zero to the time of last measurable concentration, LLOQ lower limit of quantification, max maximum, min minimum, SD standard deviation

^aSubjects with value less than LLOQ (10 ng/mL) or missing during Days 1–5

^bSubject with all values less than LLOQ (50 ng/mL) during Days 1–5