Fig. 2.

Dose proportionality test based on model-estimated AUC₂₄, which, in turn, was derived from estimated CL/F. Solid line represents geometric mean AUC₂₄, as estimated by the linear mixed-effects model of log (AUC₂₄) versus log (dose). Model-derived AUC₂₄ slope: 1.05 [0.96–1.15]_{95 % CI}. AUC area under the plasma–concentration time curve, AUC ₂₄ AUC from zero to 24 h, CL/F apparent clearance, CI confidence interval