Table 1.
Characteristics of pregnant women with multiple sclerosis who received high-dose vitamin D3 or routine care at baseline.
| Characteristics | Treatment group at baseline | P * | |||
|---|---|---|---|---|---|
| Vitamin D3 (n = 6) | Routine care (n = 9) | ||||
| Mean ± SD | n (%) | Mean ± SD | n (%) | ||
| Age (year) | 27.7 ± 2.4 | 30.0 ± 3.9 | NS | ||
| Age at pregnancy (year) | 25.3 ± 2.4 | 27.9 ± 3.9 | NS | ||
| Onset of MS to pregnancy (year) | 3.3 ± 2.2 | 5.0 ± 3.9 | NS | ||
| Relapse rate/year before pregnancy | 1.3 ± 0.5 | 1.1 ± 0.4 | NS | ||
| EDSS before pregnancy | 1.2 ± 0.3 | 1.3 ± 0.4 | NS | ||
| Serum 25(OH)D level (ng/ml) | 15.3 ± 2.9 | 18.3 ±1.9 | < 0.050 | ||
| Relapse during pregnancy | 0.0 (0.0) | 5.0 (55.6) | < 0.050 | ||
| 6-7 months | - | 2.0 (22.2) | NS | ||
| 7-8 months | - | 3.0 (33.3) | NS | ||
| Relapse up to 6 months after delivery | 0.0 (0.0) | 4.0 (44.4) | NS | ||
| 0-1 month | - | 1.0 (11.1) | NS | ||
| 2-3 months | - | 1.0 (11.1) | NS | ||
| 3-4 months | - | 2.0 (22.2) | NS | ||
*
Differences in mean (Mann–Whitney U-test) or percentage (Fisher exact test) values of variables between vitamin D3 and routine care; NS: Non-significance; MS: Multiple sclerosis; EDSS: Expanded Disability Status Scale; 25(OH)D: 25-hydroxyvitamin D; SD: Standard deviation