Figure 3.

Schematic of Notch signaling. The activation of the Notch signaling is initiated by the bind of Notch receptors to their ligands sent out from the neighboring cell. The Notch-ligand interaction then trigger the enzymolysis of ADAM and γ-secretase to Notch receptors which afterward go through three times of cleaves that make NICD separated from the Notch complex. Finally, the NICD is translocated into the nucleus where it binds to CSL (transcription repressor) and co-activator (MAML1) and initiate the expression of target genes such Hey and Hes family.