Table 2.
List of genes showing fold regulation in mRNA expression. Genes coding chromatin modification enzymes that have showed more than two fold up-regulation or down-regulation in mRNA expression in tumor tissues compared to adjacent normal tissues are listed. Most of the differentially expressed genes were up-regulated however only four genes were found down-regulated in tumor tissue compared to adjacent normal tissue
| Symbol | Description | Fold Regulation | P-value |
|---|---|---|---|
| ASH1L | Ash1 (absent, small, or homeotic)-like (Drosophila) | 3.0178 | 0.00034 |
| AURKC | Aurora kinase C | 2.2253 | 0.023647 |
| DNMT3A | DNA (cytosine-5-)-methyltransferase 3 alpha | 2.203 | 0.125805 |
| DOT1L | DOT1-like, histone H3 methyltransferase (S. cerevisiae) | 12.261 | 0.048491 |
| DZIP3 | DAZ interacting protein 3, zinc finger | 5.0613 | 0.08503 |
| EHMT2 | Euchromatic histone-lysine N-methyltransferase 2 | 2.6629 | 0.020146 |
| ESCO1 | Establishment of cohesion 1 homolog 1 (S. cerevisiae) | 2.441 | 0.00407 |
| HAT1 | Histone acetyltransferase 1 | 2.8343 | 0.080194 |
| HDAC11 | Histone deacetylase 11 | 3.7882 | 0.08619 |
| HDAC9 | Histone deacetylase 9 | 1.9684 | 0.053835 |
| KAT2A | K(lysine) acetyltransferase 2A | 3.2288 | 0.017306 |
| KAT6A | K(lysine) acetyltransferase 6A | 2.1931 | 0.056167 |
| KAT7 | K(lysine) acetyltransferase 7 | 4.131 | 0.002656 |
| KAT8 | K(lysine) acetyltransferase 8 | 2.4183 | 0.037913 |
| KDM1A | Lysine (K)-specific demethylase 1A | -3.615 | 0.172096 |
| KDM4A | Lysine (K)-specific demethylase 4A | -2.1199 | 0.226517 |
| MYSM1 | Myb-like, SWIRM and MPN domains 1 | -2.6117 | 0.194962 |
| NCOA1 | Nuclear receptor coactivator 1 | -3.8544 | 0.194186 |
| NEK6 | NIMA (never in mitosis gene a)-related kinase 6 | 3.1777 | 0.041111 |
| PRMT1 | Protein arginine methyltransferase 1 | 2.34 | 0.008843 |
| PRMT3 | Protein arginine methyltransferase 3 | 2.0406 | 0.13052 |
| PRMT6 | Protein arginine methyltransferase 6 | 3.5089 | 0.214214 |
| PRMT8 | Protein arginine methyltransferase 8 | 2.909 | 0.126327 |
| RPS6KA5 | Ribosomal protein S6 kinase, 90kDa, polypeptide 5 | 2.6786 | 0.034466 |
| SETD1A | SET domain containing 1A | 2.2276 | 0.009203 |
| SETD5 | SET domain containing 5 | 2.5874 | 0.248734 |
| SETD7 | SET domain containing (lysine methyltransferase) 7 | 2.2926 | 0.328293 |
| SETDB2 | SET domain, bifurcated 2 | 3.3081 | 0.096837 |
| SMYD3 | SET and MYND domain containing 3 | 4.0742 | 0.006322 |
| USP22 | Ubiquitin specific peptidase 22 | 3.1645 | 0.08773 |
| WHSC1 | Wolf-Hirschhorn syndrome candidate 1 | 2.5315 | 0.330608 |