Table 5.
Prognostic value of clinicopathological factors and copy number of mtDNA in univariate and multivariate Cox regression analyses (n = 124)
| Univariate analysis | Multivariate analysis | |||
|---|---|---|---|---|
|
|
||||
| Variables | Hazard Ratio (95% CI) | P | Hazard Ratio (95% CI) | P |
| Copy number of mtDNA1 | 0.38 (0.23-0.62) | < 0.001 | 0.55 (0.33-0.93) | 0.03 |
| Gender | 0.81 (0.51-1.30) | 0.38 | 0.83 (0.55-1.34) | 0.45 |
| Age2 | 1.30 (1.11-1.51) | 0.001 | 1.22 (1.05-1.42) | 0.008 |
| WHO grade3 | 3.20 (1.99-5.15) | < 0.001 | 2.55 (1.54-4.24) | < 0.001 |
| Radiotherapy | 0.46 (0.29-0.73) | 0.001 | 0.54 (0.34-0.86) | 0.01 |
1
Copy number of mtDNA (≤ 0.86 vs. > 0.86);
2
Age (per 10 years);
3
Tumor grade (I/I; III/IV).