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. 2015 Mar;70(3):207–213. doi: 10.6061/clinics/2015(03)10

Figure 2.

Figure 2

Pathological aspects of fibrolamellar hepatocellular carcinoma. (A) Surgical specimen of a large, well-circumscribed, yellow, heterogeneous mass with areas of necrosis and a central scar. (B) Histopathology of “pure fibrolamellar hepatocellular carcinoma”: large tumor cells with deeply eosinophilic cytoplasm, round, central macronucleoli, and abundant fibrous stroma arranged in thin parallel lamellae around the tumor cells. (C): Fibrolamellar hepatocellular carcinoma showing microvascular invasion; (D): “Mixed fibrolamellar hepatocellular carcinoma”: classical fibrolamellar hepatocellular carcinoma cells are found intermingled with neoplastic cells with features of conventional hepatocellular carcinoma.