Table 2.
Changes in antibody responses against P. falciparum antigens in the Papua New Guinean cohort during the course of pregnancy
| Variable (n) | SP + CQ control arm (n = 304) | SP + AZ intervention arm (n = 277) | P value |
|---|---|---|---|
| IgG to schizont extract | 0.7 | ||
| Decrease, n (%) | 70 (23.2) | 67 (24.3) | |
| No change, n (%) | 198 (65.6) | 184 (66.8) | |
| Increase, n (%) | 34 (11.3) | 25 (9.1) | |
| IgG to MSP2 | 0.6 | ||
| Decrease, n (%) | 63 (20.9) | 49 (17.8) | |
| No change, n (%) | 217 (71.9) | 203 (73.6) | |
| Increase, n (%) | 22 (7.3) | 24 (8.7) | |
| IgG to MSP3 | 0.8 | ||
| Decrease, n (%) | 55 (18.2) | 53 (19.1) | |
| No change, n (%) | 220 (72.8) | 203 (73.3) | |
| Increase, n (%) | 27 (8.9) | 21 (7.6) | |
| IgG to PfRh2 | 0.05 | ||
| Decrease, n (%) | 34 (11.2) | 39 (14.1) | |
| No change, n (%) | 244 (80.5) | 228 (82.3) | |
| Increase, n (%) | 25 (8.3) | 10 (3.6) | |
| Opsonizing IgG to E8B-ICAM | 0.004 | ||
| Decrease, n (%) | 72 (23.9) | 60 (21.7) | |
| No change, n (%) | 140 (46.5) | 164 (59.2) | |
| Increase, n (%) | 89 (29.6) | 53 (19.1) | |
| Opsonizing IgG to CS2 | 0.03 | ||
| Decrease, n (%) | 39 (13.0) | 47 (17.0) | |
| No change, n (%) | 226 (75.1) | 180 (65.2) | |
| Increase, n (%) | 36 (12.0) | 49 (17.8) |
Data represented as numbers and percentage, P-values are also shown
AZ azithromycin, CQ chloroquine, SP sulfadoxine-pyrimethamine
Significant associations (p < 0.05) highlighted in bold