Table 4.
Spearman correlation coefficients between child PKU-QOL and adolescent PKU-QOL and PedsQL scores
| PKU-QOL scores | Child evaluable population (n = 92) | Adolescent evaluable population (n = 110) | ||||||
|---|---|---|---|---|---|---|---|---|
| EF | PF | SoF | ScF | EF | PF | SoF | ScF | |
| Self-rated health status | - | - | - | - | −0.26 | −0.23 | −0.22 | −0.16 |
| Headaches | −0.07 | −0.25 | −0.05 | −0.22 | −0.23 | −0.28 | −0.22 | −0.26 |
| Stomach aches | −0.33 | −0.06 | −0.06 | −0.17 | −0.16 | −0.23 | −0.25 | −0.11 |
| Tiredness | −0.13 | −0.34 | −0.21 | −0.30 | −0.23 | −0.22 | −0.15 | −0.18 |
| Angry | −0.38 | −0.36 | −0.24 | −0.30 | −0.30 | −0.08 | −0.27 | −0.08 |
| Aggressiveness | −0.08 | −0.13 | −0.00 | −0.10 | −0.31 | −0.20 | −0.21 | −0.31 |
| Moodiness | −0.13 | −0.26 | −0.11 | −0.25 | −0.28 | −0.10 | −0.10 | −0.27 |
| Sadness | −0.41 | −0.33 | −0.33 | −0.23 | −0.31 | −0.17 | −0.23 | −0.16 |
| Anxiety | −0.26 | −0.05 | −0.31 | −0.12 | −0.27 | −0.18 | −0.27 | −0.10 |
| Lack of concentration | −0.15 | −0.32 | −0.33 | −0.36 | −0.21 | −0.19 | −0.27 | −0.48 |
| Slow thinking | −0.24 | −0.45 | −0.37 | −0.43 | −0.32 | −0.42 | −0.42 | −0.36 |
| Emotional impact of PKU | −0.45 | −0.22 | −0.28 | −0.33 | −0.47 | −0.19 | −0.31 | −0.28 |
| Practical impact of PKU | −0.40 | −0.24 | −0.25 | −0.09 | −0.29 | −0.19 | −0.30 | −0.28 |
| Social impact of PKU | −0.39 | −0.38 | −0.41 | −0.20 | −0.35 | −0.10 | −0.20 | −0.15 |
| Overall impact of PKU | −0.54 | −0.35 | −0.41 | −0.30 | −0.49 | −0.21 | −0.31 | −0.31 |
| Anxiety – blood test | −0.13 | −0.05 | −0.04 | 0.05 | −0.11 | −0.16 | −0.05 | −0.03 |
| Anxiety – blood Phe levels | −0.42 | −0.25 | −0.13 | −0.37 | −0.37 | −0.14 | −0.18 | −0.25 |
| Adherence to Phe-free protein supplements | −0.12 | −0.11 | 0.00 | −0.11 | −0.13 | −0.23 | −0.24 | −0.26 |
| Practical impact of Phe-free protein supplements | −0.23 | −0.18 | −0.21 | −0.16 | −0.43 | −0.31 | −0.36 | −0.25 |
| Guilt if poor adherence to Phe-free protein supplements | 0.14 | 0.09 | 0.01 | 0.18 | −0.11 | 0.11 | 0.04 | 0.08 |
| Relationships within family because of Phe-free protein supplements | −0.30 | −0.18 | −0.18 | −0.11 | −0.16 | −0.11 | −0.14 | −0.37 |
| Taste – Phe-free protein supplements | −0.28 | −0.06 | −0.10 | −0.23 | −0.06 | 0.00 | 0.08 | −0.17 |
| Food temptations | −0.32 | −0.29 | −0.35 | −0.14 | −0.36 | −0.10 | −0.24 | −0.18 |
| Adherence to dietary protein – restriction | −0.03 | −0.14 | −0.01 | −0.11 | −0.39 | −0.09 | −0.29 | −0.18 |
| Social impact of dietary protein restriction | −0.40 | −0.45 | −0.40 | −0.47 | −0.37 | −0.19 | −0.34 | −0.34 |
| Practical impact of dietary protein restriction | - | - | - | - | −0.44 | −0.24 | −0.30 | −0.40 |
| Overall impact of dietary protein restriction | - | - | - | - | −0.45 | −0.27 | −0.33 | −0.35 |
| Taste – specialty low-protein food | −0.12 | 0.08 | 0.13 | −0.01 | −0.19 | −0.03 | −0.09 | −0.15 |
| Food enjoyment | −0.19 | −0.23 | −0.26 | −0.11 | 0.04 | 0.03 | −0.08 | −0.08 |
| Guilt if dietary protein restriction not followed | 0.01 | −0.08 | −0.10 | −0.03 | −0.24 | −0.03 | −0.16 | −0.03 |
| Overall difficulty following dietary protein restriction | −0.32 | −0.23 | −0.24 | −0.21 | −0.37 | −0.16 | −0.19 | −0.32 |
PedsQL: Pediatric Quality-of-Life Inventory; Phe: phenylalanine; PKU: phenylketonuria; QOL: quality of life; EF: Emotional functioning; PF: Physical functioning; SoF: Social functioning; ScF: School functioning.
Moderate correlations (>0.4) are shown in bold.