Table 5.
Spearman correlation coefficients between Parent PKU-QOL and CHQ-PF28 scores in the parent evaluable population (n = 253)
| CHQ-PF28 scores | |||||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| PKU-QOL scores | PF | RP | GH | BP | PiT | PiE | RE | SE | MH | Be | FA | FC | CH |
| Child health status | −0.24 | −0.24 | −0.43 | −0.26 | −0.34 | −0.39 | −0.09 | −0.37 | −0.23 | −0.37 | −0.37 | −0.26 | 0.15 |
| Headaches | −0.06 | −0.10 | −0.29 | −0.32 | −0.18 | −0.21 | −0.12 | −0.25 | −0.29 | −0.25 | −0.22 | −0.16 | 0.16 |
| Stomach aches | −0.11 | −0.06 | −0.18 | −0.40 | −0.11 | −0.23 | −0.02 | −0.08 | −0.27 | −0.15 | −0.17 | −0.03 | 0.17 |
| Tiredness | −0.24 | −0.21 | −0.28 | −0.28 | −0.34 | −0.36 | −0.19 | −0.26 | −0.35 | −0.28 | −0.23 | −0.11 | −0.00 |
| Lack of concentration | −0.10 | −0.07 | −0.23 | −0.23 | −0.20 | −0.22 | −0.28 | −0.36 | −0.33 | −0.57 | −0.22 | −0.17 | −0.06 |
| Slow thinking | −0.16 | −0.10 | −0.29 | −0.20 | −0.20 | −0.23 | −0.40 | −0.37 | −0.36 | −0.47 | −0.26 | −0.17 | 0.03 |
| Irritability | −0.12 | −0.09 | −0.28 | −0.16 | −0.28 | −0.36 | −0.23 | −0.42 | −0.45 | −0.54 | −0.27 | −0.29 | 0.03 |
| Aggressiveness | −0.16 | −0.22 | −0.19 | −0.12 | −0.26 | −0.28 | −0.31 | −0.31 | −0.37 | −0.49 | −0.28 | −0.24 | −0.09 |
| Moodiness | −0.14 | −0.18 | −0.21 | −0.26 | −0.32 | −0.43 | −0.31 | −0.40 | −0.43 | −0.53 | −0.37 | −0.24 | −0.07 |
| Sadness | −0.16 | −0.10 | −0.25 | −0.32 | −0.36 | −0.30 | −0.36 | −0.38 | −0.43 | −0.35 | −0.28 | −0.16 | 0.03 |
| Anxiety | −0.18 | −0.15 | −0.24 | −0.18 | −0.24 | −0.16 | −0.34 | −0.39 | −0.41 | −0.20 | −0.21 | −0.21 | 0.01 |
| Emotional impact of PKU | −0.14 | −0.15 | −0.33 | −0.21 | −0.23 | −0.40 | −0.04 | −0.22 | −0.29 | −0.26 | −0.29 | −0.27 | −0.03 |
| Practical impact of PKU | −0.20 | −0.18 | −0.35 | −0.21 | −0.33 | −0.39 | −0.15 | −0.24 | −0.37 | −0.34 | −0.42 | −0.25 | 0.07 |
| Social impact of PKU | −0.20 | −0.18 | −0.29 | −0.24 | −0.26 | −0.35 | −0.20 | −0.25 | −0.33 | −0.31 | −0.37 | −0.36 | −0.03 |
| Overall impact of PKU | −0.21 | −0.20 | −0.39 | −0.26 | −0.31 | −0.46 | −0.12 | −0.29 | −0.37 | −0.35 | −0.44 | −0.34 | −0.02 |
| Anxiety – blood test | −0.15 | −0.13 | −0.14 | −0.05 | −0.21 | −0.22 | −0.03 | −0.01 | −0.15 | −0.08 | −0.27 | −0.06 | 0.08 |
| Impact of anxiety – blood test | −0.19 | −0.20 | −0.24 | −0.10 | −0.26 | −0.26 | −0.09 | 0.02 | −0.14 | −0.05 | −0.29 | −0.03 | 0.26 |
| Anxiety – blood Phe levels | −0.06 | −0.06 | −0.25 | −0.13 | −0.13 | −0.42 | −0.09 | −0.06 | −0.28 | −0.24 | −0.19 | −0.09 | 0.05 |
| Financial impact of PKU | −0.12 | −0.05 | −0.20 | −0.19 | −0.19 | −0.29 | −0.06 | −0.05 | −0.15 | −0.26 | −0.24 | −0.20 | 0.03 |
| Information on PKU | −0.14 | −0.19 | −0.25 | −0.26 | −0.14 | −0.24 | −0.14 | −0.30 | −0.16 | −0.24 | −0.19 | −0.27 | 0.00 |
| Adherence to Phe-free protein supplements | −0.09 | −0.16 | −0.10 | −0.13 | −0.11 | −0.08 | −0.22 | −0.24 | −0.21 | −0.28 | −0.12 | −0.07 | 0.03 |
| Management of Phe-free protein supplements | −0.03 | −0.12 | −0.09 | −0.10 | −0.28 | −0.21 | −0.05 | −0.07 | −0.18 | −0.28 | −0.22 | −0.14 | −0.06 |
| Practical impact of Phe-free protein supplements | −0.15 | −0.23 | −0.19 | −0.12 | −0.17 | −0.18 | −0.04 | −0.06 | −0.25 | −0.10 | −0.38 | −0.26 | −0.03 |
| Guilt if poor adherence to Phe-free protein supplements | −0.14 | −0.07 | −0.27 | −0.09 | −0.10 | −0.27 | −0.11 | 0.08 | −0.20 | −0.10 | −0.14 | −0.05 | 0.15 |
| Relationships within family because of Phe-free protein supplements | −0.17 | −0.21 | −0.15 | −0.26 | −0.33 | −0.22 | −0.15 | −0.16 | −0.24 | −0.34 | −0.32 | −0.23 | −0.02 |
| Adherence to dietary protein restriction | −0.04 | −0.09 | −0.17 | −0.08 | −0.19 | −0.11 | −0.14 | −0.15 | −0.09 | −0.24 | −0.16 | −0.10 | 0.07 |
| Management of dietary protein restriction | −0.12 | −0.16 | −0.26 | −0.25 | −0.30 | −0.40 | −0.24 | −0.34 | −0.35 | −0.49 | −0.41 | −0.29 | −0.04 |
| Practical impact of dietary protein restriction | −0.15 | −0.24 | −0.24 | −0.28 | −0.30 | −0.33 | −0.10 | −0.30 | −0.32 | −0.33 | −0.46 | −0.39 | −0.14 |
| Food enjoyment | −0.11 | −0.06 | −0.19 | −0.28 | −0.21 | −0.14 | −0.07 | −0.26 | −0.27 | −0.24 | −0.28 | −0.28 | 0.07 |
| Guilt if dietary protein restriction not followed | −0.15 | −0.04 | −0.15 | −0.07 | −0.05 | −0.31 | −0.12 | −0.00 | −0.15 | −0.07 | −0.12 | −0.04 | 0.04 |
CHQ-PF: Child Health Questionnaire–Parent Form; Phe: phenylalanine; PKU: phenylketonuria; QOL: quality of life; PF: Physical functioning; RP: Role/Social Physical; GH: General health; BP: Bodily Pain; PiT: Parent impact Time; PiE: Parent impact Emotional; RE: Role/Social Emotional; SE: Self-Esteem; MH: Mental Health; Be: Behaviour; FA: Family Activity; FC: Family Cohesion; CH: Change in Health.
Moderate correlations (>0.4) are shown in bold.