Table 6.
Spearman correlation coefficients between Adult PKU-QOL and SF-36 scores in the adult evaluable population (n = 104)
| PKU-QOL scores | SF-36 scores | |||||||
|---|---|---|---|---|---|---|---|---|
| PF | RP | BP | GH | VT | SF | RE | MH | |
| Self-rated health status | −0.37 | −0.22 | −0.30 | −0.58 | −0.57 | −0.36 | −0.29 | −0.50 |
| Headaches | −0.20 | −0.26 | −0.39 | −0.31 | −0.29 | −0.41 | −0.30 | −0.35 |
| Stomach aches | −0.17 | −0.19 | −0.40 | −0.30 | −0.34 | −0.26 | −0.33 | −0.37 |
| Tiredness | −0.28 | −0.34 | −0.30 | −0.40 | −0.52 | −0.40 | −0.32 | −0.39 |
| Lack of concentration | −0.25 | −0.59 | −0.37 | −0.40 | −0.52 | −0.51 | −0.56 | −0.60 |
| Slow thinking | −0.27 | −0.36 | −0.29 | −0.36 | −0.32 | −0.44 | −0.47 | −0.43 |
| Trembling hands | −0.16 | −0.21 | −0.19 | −0.31 | −0.31 | −0.19 | −0.25 | −0.28 |
| Irritability | −0.23 | −0.44 | −0.32 | −0.29 | −0.20 | −0.31 | −0.40 | −0.39 |
| Aggressiveness | −0.22 | −0.36 | −0.21 | −0.24 | −0.22 | −0.31 | −0.31 | −0.24 |
| Moodiness | −0.21 | −0.40 | −0.45 | −0.38 | −0.41 | −0.54 | −0.50 | −0.53 |
| Sadness | −0.21 | −0.44 | −0.48 | −0.49 | −0.39 | −0.61 | −0.56 | −0.66 |
| Anxiety | −0.16 | −0.31 | −0.26 | −0.31 | −0.29 | −0.37 | −0.43 | −0.47 |
| Emotional impact of PKU | −0.41 | −0.31 | −0.35 | −0.43 | −0.34 | −0.35 | −0.31 | −0.39 |
| Practical impact of PKU | −0.05 | −0.38 | −0.18 | −0.38 | −0.38 | −0.38 | −0.47 | −0.38 |
| Social impact of PKU | −0.34 | −0.32 | −0.30 | −0.40 | −0.30 | −0.48 | −0.35 | −0.39 |
| Overall impact of PKU | −0.27 | −0.42 | −0.42 | −0.53 | −0.32 | −0.53 | −0.45 | −0.48 |
| Anxiety – blood test | 0.05 | −0.03 | −0.27 | −0.16 | −0.12 | −0.32 | −0.22 | −0.25 |
| Anxiety – Phe levels | −0.19 | −0.11 | −0.21 | −0.28 | −0.19 | −0.25 | −0.17 | −0.15 |
| Anxiety – Phe levels during pregnancy | −0.11 | 0.11 | −0.03 | −0.02 | −0.00 | −0.05 | 0.06 | −0.13 |
| Financial impact of PKU | −0.11 | −0.05 | −0.05 | 0.14 | 0.03 | 0.01 | 0.03 | 0.08 |
| Information on PKU | −0.08 | −0.11 | −0.15 | −0.12 | −0.08 | −0.17 | −0.22 | −0.19 |
| Adherence to Phe-free protein supplements | −0.10 | −0.28 | −0.25 | −0.14 | −0.29 | −0.35 | −0.38 | −0.18 |
| Practical impact of Phe-free protein supplements | −0.13 | −0.13 | −0.11 | −0.41 | −0.43 | −0.33 | −0.25 | −0.37 |
| Guilt if poor adherence to Phe-free protein supplements | −0.12 | −0.16 | −0.23 | −0.22 | −0.13 | −0.30 | −0.13 | −0.23 |
| Relationships within family because of Phe-free protein supplements | −0.02 | −0.01 | −0.20 | −0.15 | −0.13 | −0.13 | 0.01 | −0.09 |
| Taste – Phe-free protein supplements | 0.07 | 0.12 | 0.04 | −0.24 | −0.25 | −0.18 | −0.00 | 0.00 |
| Food temptations | −0.14 | −0.40 | −0.19 | −0.21 | −0.25 | −0.37 | −0.31 | −0.33 |
| Adherence to dietary protein restriction | −0.03 | −0.29 | −0.13 | −0.06 | −0.17 | −0.24 | −0.29 | −0.29 |
| Social impact of dietary protein restriction | −0.12 | −0.40 | −0.20 | −0.43 | −0.44 | −0.50 | −0.50 | −0.49 |
| Practical impact of dietary protein restriction | −0.21 | −0.25 | −0.11 | −0.38 | −0.59 | −0.44 | −0.39 | −0.46 |
| Overall impact of dietary protein restriction | −0.23 | −0.33 | −0.17 | −0.45 | −0.57 | −0.54 | −0.44 | −0.49 |
| Taste – specialty low-protein food | −0.09 | −0.31 | −0.27 | −0.33 | −0.25 | −0.34 | −0.41 | −0.33 |
| Food enjoyment | −0.19 | −0.28 | −0.16 | −0.36 | −0.34 | −0.41 | −0.38 | −0.29 |
| Guilt if dietary protein restriction not followed | −0.17 | −0.15 | −0.21 | −0.30 | −0.10 | −0.33 | −0.12 | −0.16 |
| Overall difficulty following dietary protein restriction | −0.33 | −0.47 | −0.21 | −0.38 | −0.46 | −0.46 | −0.34 | −0.33 |
Phe: phenylalanine; PKU: phenylketonuria; QOL: quality of life; SF-36: 36-item Short Form; PF: Physical functioning; RP: Role Physical; BP: Bodily Pain; GH: General health; VT: Vitality; SF: Social Functioning; RE: Role Emotional; MH: Mental Health.
Correlations between Adult PKU-QOL and SF-36 scores were low to moderate. Moderate correlations (>0.4) are shown in bold.