Fig. 4.

Matrix ChIP analysis of changes in histone H3 lysine acetylation (H3KAc) levels at Angpt1, Tek, Kdr, and Ngal genes in experimental acute lung injury-induced sepsis (ALI-sepsis). Sheared cross-linked lungs, kidneys, and livers were assayed by using an antibody to acetylated histone H3 lysine 9 and 14, H3KAc. ChIP analysis was done as in Fig. 3. Data represent mean ± standard error of the mean (n = 12 animals from each group), expressed as a fraction of input. Statistical differences between two means (P value) are shown as in Fig. 2. ChIP, chromatin immunoprecipitation platform