Table 3.
The estimated ratio of the geometric mean number of days to recrudescence for each risk factor derived from linear regression analyses of 428 Plasmodium falciparum episodes among 354 pregnant women
| Univariablea | Multivariablea | ||||
|---|---|---|---|---|---|
| Risk factor | Categories | Nb | Ratio of geometric means (95 % CI) [P-value] | Nb | Ratio of geometric means (95 % CI) [P-value] |
| Parity | Primiparous | 93 | 0.99 (0.86, 1.14) [0.890] | 79 | 1.03 (0.89, 1.19) [0.698] |
| Multiparous | 256 | 1c | 212 | 1 | |
| Anti-malarial therapy | Artemisinin based | 49 | 1.28 (1.09, 1.51) [0.003] | 38 | 1.24 (1.07, 1.43) [0.003] |
| Non-artemisinin based | 300 | 1 | 253 | 1 | |
| Symptoms | Symptomatic | 232 | 0.89 (0.77, 1.03) [0.120] | 211 | 0.94 (0.80, 1.11) [0.459] |
| Asymptomatic | 88 | 1 | 80 | 1 | |
| Therapy supervision | Unsupervised | 86 | 0.83 (0.73, 0.94) [0.004] | 81 | 0.83 (0.73, 0.95) [0.006] |
| Supervised | 253 | 1 | 210 | 1 | |
| Intercalated P. vivax | Yes | 28 | 2.19 (1.77, 2.72) [<0.001] | 25 | 2.19 (1.76, 2.73) [<0.001] |
| No | 321 | 1 | 266 | 1 | |
| EGA (weeks) | 349 | 349 | 1.00 (0.99, 1.00) [0.217] | 291 | 1.00 (0.99, 1.00) [0.210] |
| Parasitaemia (m/L)d | 349 | 349 | 0.98 (0.97, 1.00) [0.079] | 291 | 0.98 (0.96, 0.99) [0.014] |
| Haematocrit (%) | 327 | 327 | 1.00 (0.99, 1.01) [0.618] | 291 | 1.00 (0.99, 1.01) [0.654] |
Combo, combination; Mono, monotherapy
aOutcome is time to recrudescent infection and estimates are adjusted for age, weight and study period. Univariable, linear model included a single risk factor, age, weight and study period; Multivariable, linear model included all risk factors, age, weight and study period
bThe total number of episodes (N) included in each analysis may differ from 428 due to missing risk factor data
cIndicates reference group
dParasitaemia was log2 transformed. Estimate interpreted as a 0.98-fold decrease in geometric mean time to recrudescent Pf infection(s) for a doubling in parasitaemia