Table 1.
Applications of iPSCs in liver diseases.
Applications | Diseases | iPSCs from Donor | References |
---|---|---|---|
Regenerative Medicine | fulminant hepatic failure | mouse normal iPSCs | [10] |
liver regeneration | mouse normal iPSCs | [11] | |
liver fibrosis | mouse normal iPSCs | [12] | |
chronic liver disease | mouse normal iPSCs | [13] | |
BAL | liver failure | human normal iPSCs | [14] |
Gene Therapy | A1AT deficiency | A1AT deficiency patient iPSCs | [15] |
WD | WD patient | [16] | |
Liver Diseases Model | HBV, HCV | human normal iPSCs | [17] |
HCV | human normal iPSCs | [18,19] | |
A1AT deficiency GSD, FH, Crigler-Najjar syndrome, hereditary tyrosinemia | patients iPSCs | [5,20] | |
Drug Discovery and Hepatoxicity Screening | Normal liver | patients iPSCs or human normal iPSCs | [5,21,22,23,24,25] |