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Schematic representation of mechanisms leading to chromosome mosaicism. (A) Mitotic non disjunction error involving an autosome: A mosaic 46,N/47,+chr is recovered in cytogenetic prenatal diagnosis; (B) Mitotic non-disjunction error involving a sex chromosome (X chromosome in the example): A mosaic 46,XX/47,XXX/45,X is present; (C) Meiotic non-disjunction error followed by trisomy rescue/anaphase lag: A mosaic 46,N/47,+chr is detectable.
