FIG. 3.

JM2 improves the histologic appearance of the implant/muscle interface. Hematoxylin and eosin-stained tissue sections were imaged at 10×magnification. (A) Pluronic vehicle control, (B) 1 mM ATP, (C) 180 μM JM2, (D) 180 μM JM2+1 mM ATP, (E) 200 μM FFA, and (F) 200 μM mefloquine (MFQ). * indicates implant pocket; arrows indicate implant interface. Application of JM2, FFA, and MFQ reduced formation of matrix surrounding implants and reduced cellularity of the compact matrix (indicated by {}) and loose matrix (indicated by []) adjacent to implant pockets. Note that JM2, FFA, and MFQ groups had smaller numbers of infiltrating inflammatory cells around implants. Color images available online at www.liebertpub.com/tea