Table 1.
Overview of clinical and laboratory data of the 15 natalizumab (NZB)-treated MS patients.
| NZB* | last NZB† | Routine CSF parameters | NZB (µg/ml) | CD4/CD8 | |||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Gender | Age (years) | EDSS | (months) | (weeks) | Cells/µl | QAlb‡ | IgG synthesis§ | OCB¶ | serum | CSF | PB | CSF | |
| 1 | F | 37 | 4·0 | 23 | 3·6 | 1 | 7·5(+) | Negative | Positive | 52 | 0·16 | 2·0 | 0·6 |
| 2 | F | 32 | 5·0 | 39 | n·a· | 1 | 4·1 | Negative | Negative | 65 | 0·11 | 1·5 | 0·4 |
| 3 | M | 52 | 4·0 | 35 | 4·1 | 1 | 8·1(+) | Negative | Negative | 25 | 0·09 | 1·0 | 0·3 |
| 4 | F | 45 | 6·5 | 41 | 5·9 | 1 | 5·0 | Negative | Positive | 4·3 | 0·01 | 2·0 | 2·1 |
| 5 | F | 28 | 6·0 | 60 | 3·9 | 1 | 7·0(+) | Negative | Positive | 20 | 0·05 | 1·7 | 1·4 |
| 6 | F | 20 | 3·5 | 29 | 4·1 | 0 | 3·0 | Negative | Positive | 37 | 0·03 | 1·9 | 1·0 |
| 7 | M | 31 | 6·5 | 51 | 3·3 | 2 | 13·0(+) | Negative | Negative | 52 | 0·23 | 1·7 | 0·9 |
| 8 | F | 53 | 3·0 | 35 | 7·4 | 1 | 3·5 | Positive | Positive | 49·8 | 0·1 | 5·6 | 0·7 |
| 9 | F | 38 | 4·0 | 24 | 4·7 | 1 | 3·3 | Negative | Positive | 15 | 0·03 | 2·1 | 0·4 |
| 10 | M | 40 | 1·5 | 14 | 1·0 | 1 | 10·7(+) | Negative | Positive | 109 | 0·42 | 2·7 | 0·9 |
| 11 | F | 53 | 4·5 | 12 | 2·0 | 1 | 11·2(+) | Negative | Positive | 61 | 0·24 | 1·0 | 0·5 |
| 12 | M | 34 | 4·0 | 64 | 3·6 | 2 | 9·0(+) | Negative | Positive | 59·2 | 0·17 | 2·2 | 0·4 |
| 13 | M | 23 | 2·0 | 4 | 4·0 | 6 | 7·4(+) | Positive | Positive | 39·5 | 0·13 | 0·7 | 0·3 |
| 14 | M | 43 | 4·5 | 67 | 3·1 | 3 | 5·3 | Positive | Positive | 22·3 | 0·07 | 1·6 | 0·7 |
| 15 | F | 37 | 2·0 | 17 | 3·9 | 1 | 3·1 | Negative | Positive | 39·1 | 0·05 | 1·2 | 0·5 |
Duration of NZB treatment.
time since the last NZB infusion.
QAlb (albumin quotient: CSF albumin/serum albumin × 1000) as measure for the blood–CSF-barrier integrity; (+) refers to an increased blood–CSF-barrier permeability.
intrathecal immunoglobulin (Ig)G synthesis evaluated according to Reiber [(1996) Evaluation of blood–CSF barrier function and quantification of the humoral immune response within the CNS. In: Thompson EJ, Trojano M and Livrea P (eds). CSF analysis in multiple sclerosis. Springer-Verlag: Milan, 51–72].
detection of OCB by isoelectric focusing. CSF = cerebrospinal fluid; EDSS = expanded disability status scale; F = female; M = male; OCB = oligoclonal bands; PB = peripheral blood; CD4/CD8 = CD4/CD8 T cell ratio.