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. Author manuscript; available in PMC: 2015 Dec 1.
Published in final edited form as: Kidney Int. 2015 Jan 28;87(6):1164–1175. doi: 10.1038/ki.2014.427

Fig 3.

Fig 3

Systemic inhibition of GSK3 slows cyst expansion and progression of PKD in Cys1cpk and PKD1f/f:PKHD1cre mice. Cys1cpk mice, PKD1f/f:PKHD1cre mice and their WT littermates were treated with vehicle or TDZD-8. Analysis of P14 tissue in Cys1cpk mice and P21 tissue in PKD1f/f:PKHD1cre mice are shown. (a) TDZD-8 treated Cys1cpk and PKD1f/f:PKHD1cre mice had smaller kidneys with more intact parenchyma. Scale bar=1mm, Magnified images, Scale bar=100μm (b) cyst area and (c) cyst number in Cys1cpk mice (n=6/group). (d) cyst area and (e) cyst number in PKD1f/f:PKHD1cre mice (n=6/group). (f) Kidney to body weight ratio and (g) blood urea nitrogen levels in Cys1cpk mice (n=10/ group). (h) Kidney to body weight ratio and (i) blood urea nitrogen levels in PKD1f/f:PKHD1cre mice (n=10/ group). **P<0.01, ***P<0.001, compared to vehicle treated mice.