Fig. 4. The role of caspases in cisplatin induced injury in NT3 and C2 cells.
The activities of caspase-8 (A) and caspase-9 (B) in confluent cultures of cells treated with 150 μM cisplatin for indicated time periods were determined by luminescent assay (N=2). (C) Cell viability determined by MTT assay in cells treated with indicated combinations of cisplatin, Z-IETD-FMK, Z-LEHD-FMK and Z-VAD (N=3). The asterisks indicate significant differences between NT3 and C2 cells.