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. Author manuscript; available in PMC: 2016 Jul 1.
Published in final edited form as: Apoptosis. 2015 Jul;20(7):921–929. doi: 10.1007/s10495-015-1129-x

Fig. 7. Loss of α(E)-catenin promotes Fas mediated apoptosis pathway.

Fig. 7

The expression of α(E)-catenin is decreased in aged kidney. Cisplatin causes further decrease of α(E)-catenin and promotes the Fas mediated apoptosis pathway. The pathway starts with the activation of caspase-8 and the cleavage of BID. The truncated BID (tBID) translocates to the surface of the mitochondria inducing cytochrome c release into the cytosol. The cytosolic cytochrome c activates caspase-9, followed by the activation of downstream caspase-3/-7. Bcl-2 is a negative regulator which inhibits the release of cytochrome c from mitochondria.